Organic and Medicinal Chemistry Letters

Table 1 Optimization of reaction condition for the C-S cross-coupling using CuO@ARF ^a

From: An efficient heterogeneous catalyst (CuO@ARF) for on-water C-S coupling reaction: an application to the synthesis of phenothiazine structural scaffold

Entry	Solvent	Base	Additive	Temperature/time	Yield (%)^b,c
1	Water	K₂CO₃	-	100°C/24 h	62
2^d	Water	K₂CO₃	TBAB	100°C/8 h	83
3 ^e	Water	K ₂ CO ₃	SDS	100°C/8 h	90
4^e	Water	K₂CO₃	SDS	RT/24 h	00
5^e	Water	K₂CO₃	SDS	60°C/24 h	68
6^e	Water	-	SDS	100°C/24 h	56
7	DMF	K₂CO₃	-	100°C/24 h	67

^a4-Iodoanisole (1 mmol), benzenethiol (1.2 mmol), CuO@ARF (200 mg), K₂CO₃ (1.1 mmol), and solvent (3 mL). ^bIsolated yield. ^cSmall quantity of diphenyl disulfide was formed (≤5%). ^dTBAB (1 eqv) was used. ^eSDS (10 mol%) was used.

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