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Table 2 Three component Strecker reaction using aniline (1 mmol), benzaldehyde (1 mmol) and TMSCN (1.2 mmol) in presence of indium (10 mol%) in various solvents (30 min): solvent optimization

From: A truly green synthesis of α-aminonitriles via Strecker reaction

Entry

Solvent

Yield (%)a

1

Water

98

2

THF

34

3

Ethanol

56

4

Toluene

60

5

Methanol

68

6

Dichloromethane

61

7

DMSO

76

8

THF/H2O (1:1)

54

9

Ethanol/H2O (1:1)

71

  1. aisolated yield