Table 3 Three component Strecker reaction using aniline (1 mmol), benzaldehyde (1 mmol) and TMSCN (1.2 mmol) in water (30 min): optimization of the amount of the catalyst
From: A truly green synthesis of α-aminonitriles via Strecker reaction
Entry | Indium (mol %) | Yield (%)a |
|---|---|---|
1 | 30 | 89 |
2 | 25 | 91 |
3 | 20 | 88 |
4 | 15 | 89 |
5 | 10 | 98 |
6 | 5 | 67 |
7 | 2 | 54 |
8 | 1 | 43 |