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Table 1 Details of scaffolds considered in the study and the cell lines against which their anticancer activity was reported along with the number of molecules in each cell lines and its molecular target/mechanism of action if studied.

From: Analogue-based approaches in anti-cancer compound modelling: the relevance of QSAR models

No.

Scaffold name

Cell lines

Cancer type

# of comp.

Comments

Ref.

S1

Naphthalimides

LoVo

Colon

23

DNA intercalators

[31]

  

A549

Lung

27

  
  

Hs468

Glioblastoma

23

  
  

U373-MG

Glioblastoma

29

  
  

HCT-15

Colon

25

  
  

MCF-7

Breast

20

  

S2

Aryl thiazolyl benzamide

MB-231

Breast

27

Nek2 mitotic pathway

[32]

  

MB-468

Breast

25

  
  

K562

Blood

25

  

S3

Procaspase activators

U937

Lymphoma

19

Enhance procaspase-3 activity

[33]

S4

Tylophorine analogues

KB

Nasopharyngeal

21

NF-kB signalling pathway

[34]

  

A549

Lung

21

  
  

DU-145

Prostate

21

  

S5

Parthenin analogues

HL-60

Blood

37

TopoisomeraseII inhibition

[35]

  

HeLa

Cervical

37

  

S6

Arylthiazolidine-4-acid amides

A375

Melanoma

33

-

[36]

  

B16F1

Melanoma

33

  
  

DU-145

Prostate

32

  
  

LNCaP

Prostate

35

  
  

PC-3

Prostate

31

  
  

PPC-1

Prostate

33

  
  

WM-164

Melanoma

32

  
  

Fibroblast

Fibroblast

27

  
  

RH7777

Prostate

32

  

S7

Hydroxyl benzofuranones

LNCaP

Prostate

22

Selective inhibitor of the mammalian target of rapamycin

[37]

S8

Arylthiazole-4-acid amides

B16F1

Melenoma

20

Tubulin polymerization inhibition

[38]

  

A375

Melanoma

20

  
  

DU-145

Prostate

16

  
  

PC-3

Prostate

17

  
  

LNCaP

Prostate

17

  
  

PPC-1

Prostate

18

  

S9

Estradiol 3,17-O,O-bis-sulfamates

DU-145

Prostate

29

Disruption of the tubulin-microtubule equilibrium

[39]

  

MB-231

Breast

22

  

S10

Aromathecins

SF-539

CNS

29

Inhibitors of human topoisomerase I

[40]

  

HOP-62

Lung

28

  
  

HCT-116

Colon

28

  
  

UACC-62

Melanoma

27

  
  

SN12C

Renal

26

  
  

MCF-7

Breast

29

  
  

DU-145

Prostate

23

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