From: Analogue-based approaches in anti-cancer compound modelling: the relevance of QSAR models
No. | Scaffold name | Cell lines | Cancer type | # of comp. | Comments | Ref. |
---|---|---|---|---|---|---|
S1 | Naphthalimides | LoVo | Colon | 23 | DNA intercalators | [31] |
 |  | A549 | Lung | 27 |  |  |
 |  | Hs468 | Glioblastoma | 23 |  |  |
 |  | U373-MG | Glioblastoma | 29 |  |  |
 |  | HCT-15 | Colon | 25 |  |  |
 |  | MCF-7 | Breast | 20 |  |  |
S2 | Aryl thiazolyl benzamide | MB-231 | Breast | 27 | Nek2 mitotic pathway | [32] |
 |  | MB-468 | Breast | 25 |  |  |
 |  | K562 | Blood | 25 |  |  |
S3 | Procaspase activators | U937 | Lymphoma | 19 | Enhance procaspase-3 activity | [33] |
S4 | Tylophorine analogues | KB | Nasopharyngeal | 21 | NF-kB signalling pathway | [34] |
 |  | A549 | Lung | 21 |  |  |
 |  | DU-145 | Prostate | 21 |  |  |
S5 | Parthenin analogues | HL-60 | Blood | 37 | TopoisomeraseII inhibition | [35] |
 |  | HeLa | Cervical | 37 |  |  |
S6 | Arylthiazolidine-4-acid amides | A375 | Melanoma | 33 | - | [36] |
 |  | B16F1 | Melanoma | 33 |  |  |
 |  | DU-145 | Prostate | 32 |  |  |
 |  | LNCaP | Prostate | 35 |  |  |
 |  | PC-3 | Prostate | 31 |  |  |
 |  | PPC-1 | Prostate | 33 |  |  |
 |  | WM-164 | Melanoma | 32 |  |  |
 |  | Fibroblast | Fibroblast | 27 |  |  |
 |  | RH7777 | Prostate | 32 |  |  |
S7 | Hydroxyl benzofuranones | LNCaP | Prostate | 22 | Selective inhibitor of the mammalian target of rapamycin | [37] |
S8 | Arylthiazole-4-acid amides | B16F1 | Melenoma | 20 | Tubulin polymerization inhibition | [38] |
 |  | A375 | Melanoma | 20 |  |  |
 |  | DU-145 | Prostate | 16 |  |  |
 |  | PC-3 | Prostate | 17 |  |  |
 |  | LNCaP | Prostate | 17 |  |  |
 |  | PPC-1 | Prostate | 18 |  |  |
S9 | Estradiol 3,17-O,O-bis-sulfamates | DU-145 | Prostate | 29 | Disruption of the tubulin-microtubule equilibrium | [39] |
 |  | MB-231 | Breast | 22 |  |  |
S10 | Aromathecins | SF-539 | CNS | 29 | Inhibitors of human topoisomerase I | [40] |
 |  | HOP-62 | Lung | 28 |  |  |
 |  | HCT-116 | Colon | 28 |  |  |
 |  | UACC-62 | Melanoma | 27 |  |  |
 |  | SN12C | Renal | 26 |  |  |
 |  | MCF-7 | Breast | 29 |  |  |
 |  | DU-145 | Prostate | 23 |  |  |