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Organic and Medicinal Chemistry Letters
Figure 2 | Organic and Medicinal Chemistry Letters

Figure 2

From: Synthesis and pharmacological characterization of potent, selective, and orally bioavailable isoindoline class dipeptidyl peptidase IV inhibitors

Figure 2

Pharmacological data on 4b. Top left, plasma DPP-IV activity (% change from -30 min value) in Wistar/ST rats. Data are given as mean ± SEM (n = 7). Top right, plasma insulin (pg/dL) at 10 min after glucose challenge in Wistar/ST rats. Data are given as mean ± SEM (n = 7). Bottom left, blood glucose during OGTT in Wistar/ST rats. Data are given as mean ± SEM (n = 7). Asterisks indicate significance from vehicle control at p < 0.05 (*) and p < 0.01 (**) by Dunnett's test. Bottom right, blood glucose AUC (mg min/dL) determined between 0 and 60 min during OGTT in Wistar/ST rats. Data are given as mean ± SEM (n = 7). **Significant difference from vehicle control by Dunnett's test (p < 0.01).

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