Organic and Medicinal Chemistry Letters

Table 2 PK parameters of 4b in SD rats

From: Synthesis and pharmacological characterization of potent, selective, and orally bioavailable isoindoline class dipeptidyl peptidase IV inhibitors

Route	Dose (mg/kg)	t _1/2α (h)	t _1/2α (h)	Vd _ss (L/kg)	CL _p (L/h/kg)	C _max (ng/mL)	T _max (h)	AUC _{0-9 h} (ng h/mL)	BA (%)
Iv	1	0.062	0.27	8.28	26.2	ND	ND	39
po	3	ND	1.37	ND	ND	37	0.25	33	27.7
	10	ND	1.50	ND	ND	229	0.25	156	39.9

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