Table 3 In vitro antibacterial and antifungal activities of compounds 7-12 by twofold serial dilution method
Microorganisms | Minimum inhibitory concentration (MIC) (μg/mL) | |||||||
|---|---|---|---|---|---|---|---|---|
7 | 8 | 9 | 10 | 11 | 12 | Ciprofloxacin | Fluconazole | |
Staphylococcus aureus | 50 | 12.5 | 6.25 | 25 | 200 | 100 | 25 | - |
β-Heamolytic streptococcus | 50 | 6.25 | 25 | 25 | 100 | 200 | 25 | - |
Micrococcus luteus | 6.25 | 6.25 | 25 | 25 | 200 | 200 | 12.5 | - |
Bacillus subtilis | 50 | 12.5 | 25 | 25 | 200 | 200 | 12.5 | - |
Salmonella typhii | 100 | 50 | 50 | 6.25 | 100 | 200 | 25 | - |
Shigella flexneri | 200 | 100 | 6.25 | 6.25 | 25 | 100 | 12.5 | - |
Vibreo cholerae | 100 | 25 | 6.25 | 12.5 | 50 | 100 | 25 | - |
Escherichia coli | 50 | 25 | 50 | 12.5 | 50 | 100 | 25 | - |
Pseudomonas aeruginosa | 25 | 100 | 6.25 | 12.5 | 100 | 50 | 25 | - |
Klebsiella pneumonia | 25 | 6.25 | 25 | 200 | 6.25 | 6.25 | 12.5 | - |
Aspergillus flavus | 50 | 50 | 6.25 | 200 | 50 | 100 | - | 12.5 |
Aspergillus niger | 200 | 25 | 25 | 100 | 50 | 12.5 | - | 12.5 |
Mucor indicus | 100 | 100 | 6.25 | 100 | 100 | 200 | - | 25 |
Rhizopus arrhizus | 100 | 100 | 25 | 100 | 25 | 100 | - | 25 |
Microsporum gypseum | 50 | 6.25 | 200 | 6.25 | 6.25 | 6.25 | - | 12.5 |