Increase of leishmanicidal and tubercular activities using steroids linked to aminoquinoline

Organic and Medicinal Chemistry Letters

Table 1 Effect of the compounds on promastigote forms of L. major, murine peritoneal macrophages and M. tuberculosis

Values represent the mean of triplicate samples.*AmB (amphotericin B) and isoniazid were used as reference drug for antileishmanial and anti-MTB assays, respectively. ^aIC₅₀ values (concentrations inhibiting parasite growth by 50%). ^bMIC: lowest concentration resulting in 90% inhibition of growth of MTB. ^cData have been reported previously [24].