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Organic and Medicinal Chemistry Letters

Table 1 Antinociceptive effect of BISA in capsaicin, formalin, MO, and acetic acid-induced visceral nociception in mice

From: Attenuation of visceral nociception by α-bisabolol in mice: investigation of mechanisms

Group

Dose (mg/kg)

Specific behaviors

 

Capsaicin

Formalin

MO

Acetic acid

Normal

-

10.25 ± 6.21**

198.60 ± 47.87**

21.57 ± 7.13***

-

Vehicle

-

84.38 ± 12.99

344.60 ± 50.21

107.80 ± 25.01

48.63 ± 10.81

BISA

50

87.00 ± 19.30

103.00 ± 16.21***

21.67 ± 7.99***

10.50 ± 2.94***

 

100

31.00 ± 13.11**

140.40 ± 25.51***

33.83 ± 10.28***

8.50 ± 3.20***

 

200

15.33 ± 10.82**

75.13 ± 13.44***

27.17 ± 11.05***

8.43 ± 2.57***

  1. Values represent the mean ± SEM of pain-related behaviors (licking of abdomen, stretching, abdominal retractions). **p < 0.01 and ***p < 0.001 versus vehicle (ANOVA, Student-Newman-Keul’s test).
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