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Organic and Medicinal Chemistry Letters

Table 4 Evaluation of involvement of serotonergic, nitrergic, K ATP channels, and TRPV1 receptors in the antinociceptive effect of BISA in MO test

From: Attenuation of visceral nociception by α-bisabolol in mice: investigation of mechanisms

Group

Dose (mg/kg)

Specific behaviors

Normal

-

88.25 ± 18.59**

Vehicle

-

181.90 ± 24.07

BISA

50

115.70 ± 25.33*

BISA + Ondansetron

50 + 0.5

57.13 ± 11.07***

BISA + L-NAME

50 + 20

31.25 ± 8.64***

BISA + glibenclamide

50 + 5

86.57 ± 15.61*

BISA + ruthenium red

50 + 3

61.71 ± 8.41**

  1. Values represent the mean ± SEM of pain-related behaviors (licking of abdomen, stretching, abdominal retractions). *p < 0.05, **p < 0.01 and ***p < 0.001 versus vehicle (ANOVA, Student-Newman-Keul’s test).
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