Table 5 The antibacterial and antifungal activities of 1-phenyl-3(5-bromothiophen-2-yl)-5-(substituted phenyl)-2-pyrazolines by serial dilution method
Antibacterial activities | Antifungal activities | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Entry X | MIC (μg/mL) | Entry X | MIC (μg/mL) | ||||||||
S. aureus | E. coli | K. pneumoniae | S. typhi | Pseudomonas spp. | C. albicans | Mucor spp. | Rhizopus spp. | A. niger | |||
1 | H | 25 | 50 | 12.5 | 50 | 50 | 1 | 50 | 50 | 50 | 50 |
2 | 4-Br | 50 | 25 | 3.13 | 3.13 | 6.25 | 2 | 3.13 | 3.13 | 3.13 | 3.13 |
3 | 2-Cl | 25 | 25 | 25 | 100 | 100 | 3 | 25 | 25 | 25 | 25 |
4 | 4-Cl | 200 | 50 | 25 | 25 | 25 | 4 | 25 | 25 | 25 | 3.13 |
5 | 3,4-(OCH3)2 | 6.25 | 6.25 | 12.5 | 6.25 | 3.13 | 5 | 6.25 | 6.25 | 6.25 | 6.25 |
6 | 4-I | 25 | 6.25 | 3.13 | 6.25 | 50 | 6 | 6.25 | 6.25 | 6.25 | 6.25 |
7 | 4-OCH3 | 12.5 | 6.25 | 3.13 | 6.25 | 1.5 | 7 | 3.13 | 3.13 | 3.13 | 3.13 |
8 | 4-CH3 | 50 | 100 | 50 | 200 | 200 | 8 | 50 | 50 | 50 | 50 |
Cip | - | 6.25 | 6.25 | 3.13 | 1.5 | 12.5 | Ket | 12.5 | 12.5 | 12.5 | 12.5 |