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Organic and Medicinal Chemistry Letters
Figure 4 | Organic and Medicinal Chemistry Letters

Figure 4

From: Cytotoxic and potent CYP1 inhibitors from the marine algae Cymopolia barbata

Figure 4

Eadie-Hofstee plots for inhibition of activities of CYP1A1 (A), CYP1A2(B), and CYP1B1(C) by PBQ1 along with inhibition of activities of CYP1A1 (D) and CYP1B1 (E) by PBQ2. CEC dealkylation catalyzed by recombinant CYP1A1 and CYP1A2 was determined in the absence and presence of six different concentrations of PBQs along with ERes dealkylation catalyzed by recombinant CYP1B1. Each point represents the mean ± SEM of three independent experiments.

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