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Organic and Medicinal Chemistry Letters
Figure 1 | Organic and Medicinal Chemistry Letters

Figure 1

From: Pharmacophore generation and atom-based 3D-QSAR of N-iso-propyl pyrrole-based derivatives as HMG-CoA reductase inhibitors

Figure 1

Common pharmacophore generation and validation: (a) Common pharmacophore aligned with most active ligand [two aromatic rings (dark yellow circle)], two acceptor [pink sphere with two arrows], and one negative ionic [pink sphere]; (b) common pharmacophoric sites of active ligand with distance. All distances are in Å unit; (c) alignment of all active ligands to the pharmacophore; and (d) alignment of all ligands (active and inactive) to the pharmacophore.

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