From: Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines
Compound
R
% of inhibition of virus yield (HSV-1)
1a
H
20,6
1b
9-OCH3
50,0
1c
9-CH3
68,0
1d
9-Cl
80,0
1e
8-Cl
60,0
1f
9-NO2
1g
8-NO2
87,0
1h
9-F
91,0
1i
8-F
65,0
1j
9-Br
30,0
1k
8-Br
2a
7-CH3
11,0
2b
8-CH3
ND
2c
ACV
-
96.0 ± 1.0