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Organic and Medicinal Chemistry Letters

Table 2 Anti-HSV-1 activity, cytotoxicity and SI in Vero cells for 6-chloro-3-phenyl-9-fluoro-3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine (1h)

From: Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines

Compounds

R

EC50 a (μM)

CC50 b (μM)

S.I. c

1h

9-F

0,07

600

8571

ACV

 

1.09 ± 0.25

960 ± 156

880

  1. ACV has been included for comparison purposes.
  2. a50% Effective concentration or concentration required to inhibit HSV-1 virus yield.
  3. b50% Cytotoxic concentration or concentration required to reduce the viability of host cells by 50%.
  4. cSelective index (CC50/EC50).
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