Table 1 Affinities in nM and selectivity of the tested compounds towards hCB1 and hCB2 expressed in CHO cells
Compound | hCB1 | hCB2 | Selectivity a |
|---|---|---|---|
1a | >105 | 14.4 | |
1b | >105 | >105 | |
2a | >105 | 722 | |
2b | >105 | 2,290 | |
2c | >105 | >105 | |
3b | >105 | >105 | |
4e | >105 | >105 | |
5e | >105 | 250 | |
6a | >105 | 6.98 | |
6b | 1,560 | 135 | 1.06 |
6c | >105 | 1,920 | |
6d | 7,470 | 12.5 | 2.78 |
6e | >105 | 4.27 | |
6f | >105 | 5.89 | |
6g | 397 | 2.38 | 2.22 |
6h | >105 | 39.4 | |
6i | >105 | >105 | |
6j | >105 | 5,710 | |
6k | >105 | 3,190 | |
6l | >105 | 223 | |
6m | >105 | >105 | |
7h | 6,010 | >105 | |
CP55,940 | 2.43 | 1.27 | 0.28 |
SR141716A | 1.26 | n.d.b | |
SR144528 | n.d.b | 12.0 |