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Organic and Medicinal Chemistry Letters

Table 2 Comparison of good IC50 to MIC values

From: Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors

Compound

IC50 μM

MIC

323218

0.24

+

323227

0.37

+

323228

0.30

++

323229

0.53

++

323368

0.47

-

323370

0.28

+++

332058

0.56

+++

  1. +, poor; ++, moderate; +++, good antibacterial activity.
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