Synthesis and evaluation of substituted diphenyl-1,3,4-oxadiazole derivatives for central nervous system depressant activity

Organic and Medicinal Chemistry Letters

Table 1 Anticonvulsant activity of synthesized compounds

Number	Compound	Dose (mg kg^-1)	Hind limb extensor (mean ± S.E.M)	Hind limb convulsion (mean ± S.E.M)	% Potency
1.	Control	30	27.50 ± 0.42	6.5 ± 0.47	-
2.	Standard	30	15.25 ± 0.17	6.25 ± 0.30	-
3.	XIII	30	11.50 ± 0.15**	8.16 ± 0.30	130.672
4.	XIV	30	17.33 ± 0.33***	24.33 ± 0.42**	389.28
5.	XV	30	16.83 ± 0.20*	25.83 ± 0.54***	413.28
6.	XVI	30	15.83 ± 0.27*	10.83 ± 0.30***	173.28
7.	XVII	30	11.00 ± 0.30	7.33 ± 0.33	117.32

Values are mean ± SEM of six animals in each group. Statistical significance versus standard (***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05)