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Table 2 Antidepressant activity of synthesized compounds

From: Synthesis and evaluation of substituted diphenyl-1,3,4-oxadiazole derivatives for central nervous system depressant activity

Number

Compound

Dose (mg kg-1)

0 h (mean ± S.E.M)

1 h (mean ± S.E.M)

1.

Control

10

345.83 ± 0.27

303.21 ± 0.42

2.

Standard

10

411.16 ± 0.30

91.33 ± 0.21

3.

XIII

10

401.50 ± 0.22*

85.16 ± 0.47*

4.

XIV

10

502.83 ± 0.47 ***

196.66 ± 0.42***

5.

XV

10

431.16 ± 0.30***

124.16 ± 0.40**

6.

XVI

10

455.83 ± 0.47*

89.16 ± 0.30**

7.

XVII

10

511.50 ± 0.42***

207.00 ± 0.36***

  1. Values are mean ± SEM of six animals in each group. Statistical significance versus standard (***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05)