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Organic and Medicinal Chemistry Letters

Table 4 Neurotoxic activity of the synthesized compounds

From: Synthesis and evaluation of substituted diphenyl-1,3,4-oxadiazole derivatives for central nervous system depressant activity

Compound

Dose (mg kg-1)

n

Result

Std. (Phenytoin)

30

6

X

XIII

30

6

-

XIV

30

6

X

XV

30

6

X

XVI

30

6

-

XVIII

30

6

X

  1. n, number of mice = 6; X, does not show neurotoxicity; ROA, orally; -, neurotoxicity not checked.
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