Synthesis and evaluation of substituted diphenyl-1,3,4-oxadiazole derivatives for central nervous system depressant activity

Organic and Medicinal Chemistry Letters

Table 5 Physico-chemical data of the synthesized compounds (V-VIII)

Compound	R	Molecular formula	Molecular weight	% Yield	m.p. (°C)	Rf^{solvent system}
V	4-OH	C₉H₁₀O₃	166.17	56.21	108-110	0.72^a
VI	4-NO2	C₉H₉NO₄	195.17	85.25	114-116	0.78^a
VII	4-NH2	C₉H₁₁NO₂	165.19	64.28	90-92	0.83^a
VIII	4-Cl	C₉H₉ClO₂	184.62	87.16	127-129	0.76^a