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Organic and Medicinal Chemistry Letters
Figure 3 | Organic and Medicinal Chemistry Letters

Figure 3

From: Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors

Figure 3

High-performance liquid chromatography. Isocratic semi-preparative RP-HPLC chromatograms (left) and the analytical HPLC chromatograms (right) of the radiotracers spiked with the respective reference compounds. (A) [18F]1 (t R = 35.3 min), eluent: 58% MeCN/10 mM NH4OAc aq. on a Reprosil Gold C18, 10 μm, 150 × 4.6 mm; flow rate: 2.5 mL/min. (B) [18F]2 (t R = 35.6 min), eluent: 60% MeCN/20 mM NH4OAc aq. on a Multospher 120 RP-18 AQ, 5 μm, 150 × 10 mm; flow rate: 2.0 mL/min. The precursors for radiolabelling (13 and 15) and compound 20 (see ‘Experimental’ section) were also identified by analytical HPLC on a Multospher 120 RP 18 AQ column, 5 μm, 250 × 4.6 mm; solvents: A: 10% MeCN/20 mM NH4OAc, B: 90% MeCN/20 mM NH4OAc. Gradient elution(A%): 0 to 10 min, 100%; 10 to 40 min, gradient from 100% to 0%; 40 to 45 min, 0%; 45 to 50 min, 100% at a flow rate of 1 mL/min.

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