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Organic and Medicinal Chemistry Letters
Figure 7 | Organic and Medicinal Chemistry Letters

Figure 7

From: Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors

Figure 7

In vivo metabolism conversion of [18 F]17 to [18 F]10. Analytical radio-HPLC profiles of the in vivo metabolism conversion of [18F]17 (t R = 36 min) to [18F]10 (t R = 22 min, Scheme 5b) in plasma, brain, and spleen samples. (A) At 30 min p.i. and (B) at 60 min p.i. Conditions: Multospher 120 RP 18 AQ, 5 μm, 250 × 4.6 mm. Solvents: A: 10% MeCN/20 mM NH4OAc, B: 90% MeCN/20 mM NH4OAc.Gradient elution (A%): 0 to 10 min, 100%; 10 to 40 min, gradient from 100% to 0%; 40 to 45 min, 0%; 45 to 50 min, 100% at a flow rate of 1 mL/min.

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