Skip to main content
Organic and Medicinal Chemistry Letters

Table 2 Radioactivity uptake in major organs of female CD1mice after intravenous administration of 300 to 400 kBq [ 18 F]1

From: Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors

Organ

Control (% ID/g)

Blocking (% ID/g)

 

5 mina

30 minb

60 minb

60 minc

Blood

1.94 ± 0.44

1.44 ± 0.41

1.94 ± 0.69

1.43 ± 0.34

Plasma

2.52 ± 0.58

1.88 ± 0.58

2.50 ± 0.87

1.87 ± 0.41

Brain

1.31 ± 0.24

0.76 ± 0.22

0.92 ± 0.27

0.66 ± 0.11

Heart

3.39 ± 0.45

1.43 ± 0.47

1.66 ± 0.37

1.49 ± 0.29

Lung

3.68 ± 0.62

1.65 ± 0.70

1.77 ± 0.74

1.47 ± 0.29

Stomach

2.05 ± 0.33

1.23 ± 0.36

2.70 ± 1.47

1.84 ± 1.28

Small intestine

4.36 ± 2.09

10.51 ± 8.38

22.03 ± 8.32

19.39 ± 5.53

Large intestine

1.91 ± 2.66

3.24 ± 5.61

1.54 ± 0.42

1.63 ± 0.64

Liver

11.00 ± 1.04

4.38 ± 1.19

5.29 ± 1.22

4.22 ± 0.96

Kidney

13.40 ± 5.66

2.68 ± 0.37

1.65 ± 0.49

1.74 ± 0.48

Bladder

2.23 ± 1.39

1.65 ± 0.43

3.27 ± 1.94

5.07 ± 3.84

Spleen

3.44 ± 0.77

1.46 ± 0.56

1.52 ± 0.62

0.98 ± 0.21

Thymus

3.30 ± 0.58

1.57 ± 0.80

1.90 ± 0.98

1.50 ± 0.35

Pancreas

4.97 ± 0.62

1.50 ± 0.74

1.13 ± 0.11

1.03 ± 0.26

Adrenals

4.16 ± 6.23

3.31 ± 0.99

3.16 ± 1.25

3.00 ± 0.64

Gonads

1.06 ± 0.94

1.02 ± 0.26

1.33 ± 0.50

1.19 ± 0.30

Muscle

2.10 ± 0.33

1.02 ± 0.50

0.89 ± 0.19

0.93 ± 0.23

Femur

2.00 ± 0.38

1.37 ± 0.50

1.84 ± 0.35

1.49 ± 0.45

  1. Blocking was performed with pre-administration of SR144528 (3 mg/kg i.p.). Values are mean ± SD. a n = 4, b n = 5, c n = 6.
Back to article page