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Organic and Medicinal Chemistry Letters

Table 3 Radioactivity uptake in major organs of female CD1 mice after intravenous administration of 300 to 400 kBq [ 18 F]2

From: Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors

Organ

Control (%ID/g)

Blocking (%ID/g)

 

5 min a

30 min b

60 min a

60 min a

Blood

2.29 ± 0.48

3.42 ± 0.39

2.50 ± 0.42

3.40 ± 0.21

Plasma

3.87 ± 0.90

6.82 ± 1.19

5.22 ± 0.73

5.78 ± 0.07

Brain

0.62 ± 0.22

0.86 ± 0.34

0.26 ± 0.07

0.28 ± 0.03

Heart

3.42 ± 0.57

2.32 ± 0.24

1.45 ± 0.20

1.53 ± 0.13

Lung

4.62 ± 0.21

3.36 ± 0.02

2.52 ± 0.60

2.31 ± 0.19

Stomach

1.57 ± 1.18

2.09 ± 0.81

2.21 ± 0.43

3.24 ± 2.10

Small intestine

3.86 ± 2.64

20.78 ± 3.28

27.31 ± 2.44

29.64 ± 5.10

Large intestine

0.46 ± 0.06

1.25 ± 0.30

1.86 ± 0.36

1.78 ± 0.23

Liver

31.31 ± 9.91

8.84 ± 0.83

6.27 ± 0.68

10.51 ± 1.10

Kidney

5.86 ± 0.96

5.90 ± 0.15

3.96 ± 1.25

4.91 ± 1.51

Bladder

1.01 ± 0.29

2.02 ± 0.39

1.45 ± 0.57

1.77 ± 0.16

Spleen

10.42 ± 7.67

1.34 ± 0.10

0.68 ± 0.11

0.74 ± 0.10

Thymus

2.30 ± 1.06

1.96 ± 0.22

1.04 ± 0.08

1.77 ± 0.14

Pancreas

2.04 ± 0.59

1.71 ± 0.15

0.82 ± 0.21

1.02 ± 0.11

Adrenals

7.67 ± 2.18

5.38 ± 0.61

2.44 ± 0.72

3.34 ± 0.15

Gonads

1.14 ± 0.32

2.08 ± 0.03

2.29 ± 0.57

1.97 ± 0.39

Muscle

1.00 ± 0.30

0.92 ± 0.15

0.70 ± 0.27

0.70 ± 0.06

Femur

1.63 ± 0.93

1.10 ± 0.03

0.58 ± 0.11

0.61 ± 0.09

  1. Blocking was performed with pre-administration of SR144528 (3 mg/kg i.p.). Values are mean ± SD. a n = 3, b n = 2.
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