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Organic and Medicinal Chemistry Letters

Table 4 Relative percentages of intact tracer and radiometabolites in plasma samples

From: Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors

Compound

t R(min)a

Plasma

  

30 min p.i. (%)

60 min p.i. (%)

[18F]1

38.8

60

7

M1 a

4.2

36

92

M2 a

30.2

3

1

[18F]2

41.7

2

2

M1 b

22.9

95

88

M2 b

36.4

≤1

≤1

  1. At 30 and 60 min p.i. of [18F]1 and [18F]2. aRadio-HPLC (separation conditions, see ‘Experimental’ section).
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