Ultrasound-assisted synthesis of 2,4-thiazolidinedione and rhodanine derivatives catalyzed by task-specific ionic liquid: [TMG][Lac]

Organic and Medicinal Chemistry Letters

Table 1 Synthesis of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione 4a via Knoevenagel condensation of 2a with 3a employing different ILs as catalyst

The reaction conditions for (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione 4a are as follows: 2a (1 mmol), 3a (1 mmol), and catalysts (20 mol%) were irradiated under ultrasound irradiations at 80°C. The product was characterized by spectral techniques like IR, ¹H NMR, ¹³C NMR, and mass spectra. ^aIsolated yields after recrystallization.