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Table 2 Anticancer activity of synthesized compounds

From: Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors

Compound code

  

IC 50of cell line types (tissue/cell)

 

THP-1

A-549

MCF-7

IGROV-1

HEP-2

DU-145

 

(WBC)

(lung)

(breast)

(ovary)

(liver)

(prostrate)

2a

>100

>100

86.9

>100

>100

>100

2b

>100

>100

>100

>100

-

-

2c

89.2

71.0

>100

>100

-

-

2d

0.80

>100

0.37

38.0

63.4

40.4

2e

73.0

>100

>100

>100

-

-

2f

81.3

>100

>100

>100

>100

>100

2 g

70.6

>100

>100

-

89

>100

2 h

>100

>100

>100

-

>100

-

2i

-

-

>100

-

-

-

2j

>100

>100

76.1

-

-

16.4

2 k

>100

>100

50.0

-

-

43.9

2 l

86.0

>100

76.4

>100

>100

>100

2 m

67.0

75.7

>100

>100

>100

>100

2n

>100

>100

>100

>100

-

-

2o

>100

>100

>100

>100

-

-

2p

>100

>100

>100

>100

-

-

2q

68.0

>100

79.0

>100

>100

>100

2r

40.8

38.7

51.9

>100

>100

>100

2 s

>100

90.3

>100

>100

>100

>100

2 t

-

>100

>100

-

>100

>100

2u

>100

>100

>100

>100

>100

>100

2v

>100

>100

95.2

>100

-

-

2w

>100

>100

51.8

>100

-

-

2x

92.0

>100

>100

>100

>100

>100

2y

81.8

49.8

3.6

>100

85.3

-

Adriamycin

0.12

0.11

0.16

0.19

-

-

Mitomycin

0.23

0.19

0.27

0.25

0.31

-

Paclitaxel

0.15

-

-

0.15

0.14

-

5-fluorouracil

9.7

8.6

9.9

8.3

9.7

9.1