From: Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors
Compound code | IC 50of cell line types (tissue/cell) | |||||
---|---|---|---|---|---|---|
THP-1 | A-549 | MCF-7 | IGROV-1 | HEP-2 | DU-145 | |
(WBC) | (lung) | (breast) | (ovary) | (liver) | (prostrate) | |
2a | >100 | >100 | 86.9 | >100 | >100 | >100 |
2b | >100 | >100 | >100 | >100 | - | - |
2c | 89.2 | 71.0 | >100 | >100 | - | - |
2d | 0.80 | >100 | 0.37 | 38.0 | 63.4 | 40.4 |
2e | 73.0 | >100 | >100 | >100 | - | - |
2f | 81.3 | >100 | >100 | >100 | >100 | >100 |
2 g | 70.6 | >100 | >100 | - | 89 | >100 |
2 h | >100 | >100 | >100 | - | >100 | - |
2i | - | - | >100 | - | - | - |
2j | >100 | >100 | 76.1 | - | - | 16.4 |
2 k | >100 | >100 | 50.0 | - | - | 43.9 |
2 l | 86.0 | >100 | 76.4 | >100 | >100 | >100 |
2 m | 67.0 | 75.7 | >100 | >100 | >100 | >100 |
2n | >100 | >100 | >100 | >100 | - | - |
2o | >100 | >100 | >100 | >100 | - | - |
2p | >100 | >100 | >100 | >100 | - | - |
2q | 68.0 | >100 | 79.0 | >100 | >100 | >100 |
2r | 40.8 | 38.7 | 51.9 | >100 | >100 | >100 |
2 s | >100 | 90.3 | >100 | >100 | >100 | >100 |
2 t | - | >100 | >100 | - | >100 | >100 |
2u | >100 | >100 | >100 | >100 | >100 | >100 |
2v | >100 | >100 | 95.2 | >100 | - | - |
2w | >100 | >100 | 51.8 | >100 | - | - |
2x | 92.0 | >100 | >100 | >100 | >100 | >100 |
2y | 81.8 | 49.8 | 3.6 | >100 | 85.3 | - |
Adriamycin | 0.12 | 0.11 | 0.16 | 0.19 | - | - |
Mitomycin | 0.23 | 0.19 | 0.27 | 0.25 | 0.31 | - |
Paclitaxel | 0.15 | - | - | 0.15 | 0.14 | - |
5-fluorouracil | 9.7 | 8.6 | 9.9 | 8.3 | 9.7 | 9.1 |