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Table 2 Anticancer activity of synthesized compounds

From: Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors

Compound code    IC 50of cell line types (tissue/cell)
  THP-1 A-549 MCF-7 IGROV-1 HEP-2 DU-145
  (WBC) (lung) (breast) (ovary) (liver) (prostrate)
2a >100 >100 86.9 >100 >100 >100
2b >100 >100 >100 >100 - -
2c 89.2 71.0 >100 >100 - -
2d 0.80 >100 0.37 38.0 63.4 40.4
2e 73.0 >100 >100 >100 - -
2f 81.3 >100 >100 >100 >100 >100
2 g 70.6 >100 >100 - 89 >100
2 h >100 >100 >100 - >100 -
2i - - >100 - - -
2j >100 >100 76.1 - - 16.4
2 k >100 >100 50.0 - - 43.9
2 l 86.0 >100 76.4 >100 >100 >100
2 m 67.0 75.7 >100 >100 >100 >100
2n >100 >100 >100 >100 - -
2o >100 >100 >100 >100 - -
2p >100 >100 >100 >100 - -
2q 68.0 >100 79.0 >100 >100 >100
2r 40.8 38.7 51.9 >100 >100 >100
2 s >100 90.3 >100 >100 >100 >100
2 t - >100 >100 - >100 >100
2u >100 >100 >100 >100 >100 >100
2v >100 >100 95.2 >100 - -
2w >100 >100 51.8 >100 - -
2x 92.0 >100 >100 >100 >100 >100
2y 81.8 49.8 3.6 >100 85.3 -
Adriamycin 0.12 0.11 0.16 0.19 - -
Mitomycin 0.23 0.19 0.27 0.25 0.31 -
Paclitaxel 0.15 - - 0.15 0.14 -
5-fluorouracil 9.7 8.6 9.9 8.3 9.7 9.1