β-Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies

Table 4 Docking results of synthesized compounds in the binding site of vascular endothelial growth factor receptor-2

Compound number	Total energy	Z score	VDW
1	−75.0934	−72.2	−79.4166
2	−78.2062	−75.1	−69.6532
3	−70.5653	−95.6	−68.46
4	−78.7892	−72.3	−63.191
5	−65.564	−78.9	−59.3404
6	−86.6543	−105.7	−80.5888
7	−71.8927	−63.17	−59.0905
8	−95.9923	−120.5	−94.7849
9	−79.948	−71.9	−56.0692
10	−73.5766	−80	−86.6021
11	−72.3245	−73.6	−73.1902
12	−75.4277	−72.2	−70.7142
13	−85.3265	−94.6	−54.4274
14	−75.329	−75.3	−71.2839
15	−80.914	−75.1	−73.6739
16	−75.3033	−91.5	−63.0176
17	−68.7853	−74.3	−69.6841
18	−104.9856	−125.5	−105.697
19	−92.6464	−115.2	−87.8944
20	−74.3443	76.7	−70.902
21	−62.3597	−73.3	−50.6291
22	−60.2348	−78.2	−65.3015
23	−77.191	−75.6	−63.8723
24	−82.723	−77.2	−68.4238
25	−80.73	−75	−56.4072
26	−75.093	−104.3	−48.6469