β-Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies

Organic and Medicinal Chemistry Letters

Table 6 Cytotoxic activity of the newly synthesized compounds 1 to 26

	Concentration (μg/mL)	Percentage of cytotoxicity/anti-proliferation
	Concentration (μg/mL)	Panc1 (pancreas)	ACHN (renal)	HCT116 (colon)
Compound number
1	10	−75	−7	−138
2	10	−64	5	1
3	10	−78	0	−16
4	10	−10	20	−12
5	10	−20	−3	6
6	10	−101	−25	−116
7	10	14	−16	−115
8	10	−15	−31	−107
9	10	−56	19	8
10	10	−75	−7	−138
11	10	−117	7	−107
12	10	−89	13	−70
13	10	−14	3	5
14	10	−118	−19	−123
15	10	12	5	17
16	10	−71	−10	−112
17	10	−51	4	−102
18	10	4	−41	−128
19	10	−10	−26	−80
20	10	71	73	79
21	10	−80	−5	−20
23	10	12	−7	−6
24	10	6	2	−103
25	10	−45	−18	−64
26	10	−7	−12	1
Tannase	10	17.3	12.4	9.7