Design and synthesis of tetrahydrophthalimide derivatives as inhibitors of HIV-1 reverse transcriptase

Organic and Medicinal Chemistry Letters

Table 2 Predicted molecular parameters of the synthesized compounds

Compound code	CLogP	Molecular weight	Number of HBA	Number of HBD	Solubility	Drug likeness	Drug score
4a	1.10	284	5	1	−2.45	2.29	0.7
4b	1.00	314	6	1	−2.47	2.67	0.34
4c	1.42	298	5	1	−2.79	2.54	0.42
4d	1.72	318	5	1	−3.19	4.71	0.69
4e	1.00	314	6	1	−2.47	3.65	0.43
4f	1.42	298	5	1	−2.79	3.56	0.71
4g	1.72	318	5	1	−3.19	3.93	0.69
4h	1.00	314	6	1	−2.47	4.05	0.72
4i	1.42	298	5	1	−2.79	4.07	0.71
4j	1.72	318	5	1	−3.19	4.17	0.55
4k	0.97	329	8	1	−2.91	−11.4	0.28
4l	0.97	329	8	1	−2.91	−1.34	0.27
4m	0.97	329	8	1	−2.91	−3.08	0.22
4n	1.74	312	5	1	−3.14	0.76	0.47
4o	1.74	312	5	1	−3.14	−0.22	0.32
4p	2.03	332	5	1	−3.53	3.93	0.66