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Table 1 In vitro antibacterial activity and MIC of compounds 4 and 5 using agar well diffusion method

From: Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents

Compound a

Diameter of zone of inhibition in mm (MIC) b

B. subtilis

S. aureus

P. fluorescens

E. coli

4a

28 ± 0.00 (0.04)

26 ± 0.30 (0.4)

14 ± 0.08 (400)

14 ± 0.46 (400)

4b

20 ± 0.19 (4.0)

24 ± 0.50 (0.4)

15 ± 0.09 (400)

14 ± 0.23 (400)

4c

16 ± 0.19 (40)

24 ± 0.32 (0.4)

-

14 ± 0.23 (400)

4d

16 ± 0.00 (40)

12 ± 0.19 (400)

-

14 ± 0.43 (400)

4e

12 ± 0.40 (400)

16 ± 0.22 (40)

-

20 ± 0.30 (4)

4f

24 ± 0.07 (0.4)

20 ± 0.37 (4.0)

14 ± 0.14 (400)

18 ± 0.33 (40)

4g

14 ± 0.23 (400)

12 ± 0.10 (400)

-

20 ± 0.34 (4)

5a

28 ± 0.09 (0.04)

30 ± 0.15 (0.04)

-

20 ± 0.32 (4)

5b

16 ± 0.32 (40)

25 ± 0.42 (0.4)

16 ± 0.12 (40)

14 ± 0.50 (400)

5c

14 ± 0.18 (400)

22 ± 0.24 (40)

 

18 ± 0.54 (40)

5d

22 ± 0.09 (4.0)

22 ± 0.20 (4.0)

16 ± 0.23 (40)

20 ± 0.12 (4)

5e

14 ± 0.00 (400)

16 ± 0.00 (40)

25 ± 0.13 (0.4)

18 ± 0.23 (40)

5f

12 ± 0.33 (400)

16 ± 0.36 (40)

-

16 ± 0.43 (40)

5g

14 ± 0.32 (400)

12 ± 0.30 (400)

14 ± 0.43 (400)

20 ± 0.21 (4)

Ciprofloxacin

26 ± 0.025 (0.4)

26 ± 0.45 (0.4)

23 ± 0.42 (4.0)

25 ± 0.44 (0.4)

  1. MIC (μg/mL), minimum inhibitory concentration. Hyphens denote no activity. aThe concentration is 4.0 mg/mL. bThe values, including the diameter of the well (8 mm), are means of the three replicates.