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Table 2 In vitro antifungal activity and MIC of compounds 4 and 5 using agar well diffusion method

From: Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents

Compound a

Diameter of zone of inhibition in mm (MIC) b

 

Candida albicans

Saccharomyces cerevisiae

4a

12 ± 0.43 (400)

28 ± 0.15 (0.04)

4b

12 ± 0.56 (400)

16 ± 0.38 (40)

4c

12 ± 0.54 (400)

16 ± 0.40 (40)

4d

14 ± 0.14 (400)

20 ± 0.45 (4.0)

4e

12 ± 0.45 (400)

18 ± 0.16 (40)

4f

12 ± 0.32 (400)

16 ± 0.27 (40)

4g

16 ± 0.27 (40)

18 ± 0.48 (40)

5a

12 ± 0.32 (400)

16 ± 0.00 (40)

5b

12 ± 0.33 (400)

28 ± 0.28 (0.04)

5c

-

16 ± 0.00 (40)

5d

12 ± 0.23 (400)

18 ± 0.18 (40)

5e

13 ± 0.37 (400)

22 ± 0.44 (4.0)

5f

-

16 ± 0.30 (40)

5g

12 ± 0.43 (400)

20 ± 0.10 (4.0)

Fluconazole

16 ± 0.45 (40)

24 ± 0.50 (40)

  1. MIC (μg/mL), minimum inhibitory concentration. Hyphen denotes no activity. aThe concentration is 4.0 mg/mL. bThe values, including the diameter of the well (8 mm), are means of the three replicates.