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Table 3 Growth inhibition (GI 50 μM) of isoaplysin (1), isolaurenisol (2), and debromoaplysinol (4) against a panel of cancer and non-cancer derived cell lines

From: Cytotoxic compounds from Laurencia pacifica

  Compound
Cell line 1 2 4
HT29a 15 ± 1.2 >50 9.1 ± 1.1
U87b 40 ± 0.6 >50 26 ± 1.7
MCF-7c 20 ± 1.3 >50 14 ± 1.7
A2780d 17 ± 0.6 >50 10 ± 1.7
H460e 34 ± 1.2 >50 18 ± 0.3
A431f 17 ± 0.6 >50 9.6 ± 0.9
Du145g 12 ± 0.3 >50 6.8 ± 0.3
BE2-Ch 27 ± 2.3 >50 13 ± 0.9
SJ-G2b 29 ± 0.7 >50 15 ± 0.7
MIAi 23 ± 1.5 >50 16 ± 0.7
SMAj 24 ± 3.8 >50 14 ± 1.2
MCF10Ak 46 ± 3.2 >50 28 ± 1.0
  1. GI50 is the concentration of drug that reduces cell growth by 50%. aColon; bglioblastoma; cbreast; dovarian; elung; fskin; gprostate; hneuroblastoma; ipancreas; jglioblastoma (murine); kbreast (normal).