Table 3 Growth inhibition (GI 50 μM) of isoaplysin (1), isolaurenisol (2), and debromoaplysinol (4) against a panel of cancer and non-cancer derived cell lines
Compound | |||
|---|---|---|---|
Cell line | 1 | 2 | 4 |
HT29a | 15 ± 1.2 | >50 | 9.1 ± 1.1 |
U87b | 40 ± 0.6 | >50 | 26 ± 1.7 |
MCF-7c | 20 ± 1.3 | >50 | 14 ± 1.7 |
A2780d | 17 ± 0.6 | >50 | 10 ± 1.7 |
H460e | 34 ± 1.2 | >50 | 18 ± 0.3 |
A431f | 17 ± 0.6 | >50 | 9.6 ± 0.9 |
Du145g | 12 ± 0.3 | >50 | 6.8 ± 0.3 |
BE2-Ch | 27 ± 2.3 | >50 | 13 ± 0.9 |
SJ-G2b | 29 ± 0.7 | >50 | 15 ± 0.7 |
MIAi | 23 ± 1.5 | >50 | 16 ± 0.7 |
SMAj | 24 ± 3.8 | >50 | 14 ± 1.2 |
MCF10Ak | 46 ± 3.2 | >50 | 28 ± 1.0 |