Organic and Medicinal Chemistry Letters

Table 2 Antipromastigote activity (IC ₅₀ ) of the synthesized compounds

From: Synthesis and antileishmanial evaluation of some 2,3-disubstituted-4(3H)-quinazolinone derivatives

Test compounds	IC₅₀values (μg/ml)	IC₅₀values (ng/ml)
6	0.3014	301.40
7	0.0128	12.80
8	0.1085	108.50
9	2.7017	2,701.70
11	0.1086	108.60
12	1.6472	1,647.20
13	3.1085	3,108.50
Miltefosine	3.1911	3,191.10
Amphotericin B	0.0460	46.00

IC₅₀: effective concentration required to achieve 50% growth inhibition (in μg/ml).

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