Table 1 Cytotoxic activity (IC 50 μM) of compounds 8a-i
From: Synthesis and biological evaluation of benzimidazole-linked 1,2,3-triazole congeners as agents
Compound | A375 | B-16 | Colon-205 | MCF-7 | A-549 |
|---|---|---|---|---|---|
8a | 2.7 | - | 1.3 | 3.2 | 0.1 |
8b | 2.3 | 1.9 | 3.5 | 1.7 | 2.6 |
8c | 1.6 | 16 | 0.12 | 1.9 | - |
8d | - | 4.7 | 8 | - | - |
8e | 2.1 | - | 1.3 | 0.3 | 1.8 |
8f | 15 | 3.9 | 17 | - | - |
8g | 43 | - | 32 | - | 26 |
8h | - | - | - | 37 | 32 |
8i | 27 | 10 | 21 | - | - |
ADR | 0.9 | 1.0 | 3.5 | 3.2 | 0.03 |