Organic and Medicinal Chemistry Letters

Table 2 Synthesis of 3-aminoalkylated indoles (4a-t) catalyzed by AgOTf

From: Silver triflate catalyzed synthesis of 3-aminoalkylated indoles and evaluation of their antibacterial activities

Number	R	R'	R''	R'''	Product	Yield (%)^a
1	H	H	4-Cl	CH₃	4a	86^b
2	H	H	4-CH₃	CH₃	4b	85
3	H	H	4-CH₃O	CH₃	4c	84
4	H	H	H	CH₃	4d	76
5	H	H	4-OH	CH₃	4e	77
6	H	H	3-Br, 4-OH	CH₃	4f	85
7	H	H	3-CH₃O	CH₃	4g	83
8	H	H	2,4-CH₃O	CH₃	4h	80
9	H	CH₃	H	CH₃	4i	77
10	H	CH₃	4-Cl	CH₃	4j	76
11	H	CH₃	4-CH₃	CH₃	4k	77
12	H	H	3-NO₂	CH₃	4l	48
13	5-Br	H	H	CH₃	4m	75
14	5-OCH₃	H	4-OCH₃	CH₃	4n	85
15	5-OCH₃	H	4-CH₃	CH₃	4o	82
16	5-Br	H	4-CH₃	CH₃	4p	80
17	5-Br	H	4-OCH₃	CH₃	4q	79
18	5-OCH₃	H	4-Cl	CH₃	4r	81
19	5-OCH₃	H	4-Cl	H	4s	45

^aIsolated yield.
^bYield for four consecutive cycles for recycled AgOTf were 86, 84, 80 and 78, respectively.

Back to article page