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  1. Content type: Original article

    Nanotechnology is now regarded as a distinct field of research in modern science and technology with multifaceted areas including biomedical applications. Among the various approaches currently available for t...

    Authors: Goutam Brahmachari, Sajal Sarkar, Ranjan Ghosh, Soma Barman, Narayan C Mandal, Shyamal K Jash, Bubun Banerjee and Rajiv Roy

    Citation: Organic and Medicinal Chemistry Letters 2014 4:18

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  2. Content type: Original article

    Aryl sulfides have significant importance from biological and pharmaceutical aspects. Transition metal-catalyzed carbon-sulfur cross-coupling reaction represents an important tool for the synthesis of sulfides...

    Authors: Debasish Sengupta and Basudeb Basu

    Citation: Organic and Medicinal Chemistry Letters 2014 4:17

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  3. Content type: Short communication

    1,8-Naphthyridine derivatives have attracted considerable attention because the 1,8-naphthyridine skeleton is present in many compounds that have been isolated from natural substances, with various biological ...

    Authors: Mallaiah Bucha, Laxminarayana Eppakayala, Thirumala Chary Maringanti, Giri Tharikoppula and Shashikala Kethireddy

    Citation: Organic and Medicinal Chemistry Letters 2014 4:16

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  4. Content type: Original article

    A rapid and sensitive ultraviolet-visible (UV-VIS) spectroscopic method was developed for the estimation of pyrimidine derivative 6-Bromo-3-(6-(2,6-dichlorophenyl)-2-(morpolinomethylamino) pyrimidine4-yl) -2H-...

    Authors: Anshu Chaudhary, Anoop Singh and Prabhakar Kumar Verma

    Citation: Organic and Medicinal Chemistry Letters 2014 4:15

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  5. Content type: Short communication

    Benzimidazoles and triazoles are useful structures for research and development of new pharmaceutical molecules and have received much attention in the last decade because of their highly potent medicinal acti...

    Authors: Karna Ji Harkala, Laxminarayana Eppakayala and Thirumala Chary Maringanti

    Citation: Organic and Medicinal Chemistry Letters 2014 4:14

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  6. Content type: Original article

    Macrotyloma uniflorum Linn (Fabaceae) is a herbaceous plant with annual branches. It is used in kidney stones, inflamed joints, fever, musculoskeletal disorders, sinus wounds and localized abdominal tumors. It is...

    Authors: Sneha Das, Neeru Vasudeva and Sunil Sharma

    Citation: Organic and Medicinal Chemistry Letters 2014 4:13

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  7. Content type: Short communication

    The current investigation sought to explore the nature of the secondary metabolites in the algae, Laurencia pacifica.

    Authors: Diana A Zaleta-Pinet, Ian P Holland, Mauricio Muñoz-Ochoa, J Ivan Murillo-Alvarez, Jennette A Sakoff, Ian A van Altena and Adam McCluskey

    Citation: Organic and Medicinal Chemistry Letters 2014 4:8

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  8. Content type: Short communication

    Azaheterocycles are an important class of compounds because of their highly potent medicinal activities, and the imidazole subcategory is of special interest in regard to drug discovery research.

    Authors: Debasish Bandyopadhyay, Lauren C Smith, Daniel R Garcia, Ram N Yadav and Bimal K Banik

    Citation: Organic and Medicinal Chemistry Letters 2014 4:9

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  9. Content type: Original article

    Leishmaniasis is a neglected tropical parasitic diseases affecting millions of people around the globe. Quinazolines are a group of compounds with diverse pharmacological activities. Owing to their promising a...

    Authors: Yihenew Simegniew Birhan, Adnan Ahmed Bekhit and Ariaya Hymete

    Citation: Organic and Medicinal Chemistry Letters 2014 4:10

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  10. Content type: Original article

    Malaria is an endemic disease affecting many countries in Tropical regions. In the search for compound hits for the design and/or development of new drugs against the disease, many research teams have resorted...

    Authors: Pascal Amoa Onguéné, Fidele Ntie-Kang, James Ajeck Mbah, Lydia Likowo Lifongo, Jean Claude Ndom, Wolfgang Sippl and Luc Meva′a Mbaze

    Citation: Organic and Medicinal Chemistry Letters 2014 4:6

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  11. Content type: Original article

    A series of 6-(substituted aldehyde)-3,4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-(hydroxymethyl) furan-2-yl)-4-phenylpyrimidine-2(1H)-one derivative (6A-6P) was synthesized from the 6-(substituted aldehyde)-4-pheny...

    Authors: Rupesh Dudhe, Pramod Kumar Sharma and Prabhakar Kumar Verma

    Citation: Organic and Medicinal Chemistry Letters 2014 4:3

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  12. Content type: Original article

    The aim of the current investigation was to identify bioactive secondary metabolites including phenols, tannins, flavonoids, terpinedes, and steroids and compare the phytochemical analysis and antioxidant prof...

    Authors: Abdur Rauf, Ghias Uddin and Jawad Ali

    Citation: Organic and Medicinal Chemistry Letters 2014 4:5

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  13. Content type: Original article

    The aim of this study was to evaluate the effects of nitroxin biofertilizer and chemical fertilizer on the growth, yield, and essential oil composition of dill. The experiment was conducted under field conditi...

    Authors: Fatemeh Nejatzadeh-Barandozi and Fathollah Gholami-Borujeni

    Citation: Organic and Medicinal Chemistry Letters 2014 4:4

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  14. Content type: Original article

    Phenylazonaphtol-β-D-O-glycosides are alternative substrates for the detection of enzymatic activity of β-glycosidases which are involved in various important processes. These azoic compounds are currently exploi...

    Authors: Marco Brito-Arias, Carlos Aguilar-Lemus, Pamela B Hurtado-Ponce, Guadalupe Martínez-Barrón and Miguel Ibañez-Hernandez

    Citation: Organic and Medicinal Chemistry Letters 2014 4:2

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  15. Content type: Original article

    The level of expression of cannabinoid receptor type 2 (CB2R) in healthy and diseased brain has not been fully elucidated. Therefore, there is a growing interest to assess the regional expression of CB2R in the b...

    Authors: Rodrigo Teodoro, Rareş-Petru Moldovan, Corinna Lueg, Robert Günther, Cornelius K Donat, Friedrich-Alexander Ludwig, Steffen Fischer, Winnie Deuther-Conrad, Bernhard Wünsch and Peter Brust

    Citation: Organic and Medicinal Chemistry Letters 2013 3:11

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  16. Content type: Original article

    Drug metabolism and pharmacokinetic (DMPK) assessment has come to occupy a place of interest during the early stages of drug discovery today. Computer-based methods are slowly gaining ground in this area and a...

    Authors: Fidele Ntie-Kang, James A Mbah, Lydia L Lifongo, Luc C Owono Owono, Eugene Megnassan, Luc Meva'a Mbaze, Philip N Judson, Wolfgang Sippl and Simon MN Efange

    Citation: Organic and Medicinal Chemistry Letters 2013 3:10

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  17. Content type: Original article

    Pyrazole and pyrazolone motifs are well known for their wide range of biological activities such as antimicrobial, anti-inflammatory, and antitumor activities. The incorporation of more than one pharmacophore ...

    Authors: Poonam Khloya, Pawan Kumar, Arpana Mittal, Neeraj K Aggarwal and Pawan K Sharma

    Citation: Organic and Medicinal Chemistry Letters 2013 3:9

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  18. Content type: Original article

    Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are one of the key components in highly active anti-retroviral therapy because of their high specificity and less toxicity. NNRTIs inhibit reverse trans...

    Authors: Ashok Penta, Swastika Ganguly and Sankaran Murugesan

    Citation: Organic and Medicinal Chemistry Letters 2013 3:8

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    The Erratum to this article has been published in Organic and Medicinal Chemistry Letters 2013 3:12

  19. Content type: Original article

    We report the synthesis of benzimidazoles using lanthanum chloride as an efficient catalyst. One-pot synthesis of 2-substituted benzimidazole derivatives from o-phenylenediamine and a variety of aldehydes were de...

    Authors: Yekkirala Venkateswarlu, Sudhagani Ramesh Kumar and Panuganti Leelavathi

    Citation: Organic and Medicinal Chemistry Letters 2013 3:7

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  20. Content type: Original article

    Pyrazolones are traditionally synthesized by the reaction of β-keto esters with hydrazine and its derivatives. There are methods to synthesize β-keto esters from esters and aldehydes, but these methods have ma...

    Authors: Ramasamy Venkat Ragavan, Kalavathi Murugan Kumar, Vijayaparthasarathi Vijayakumar, Sundaramoorthy Sarveswari, Sudha Ramaiah, Anand Anbarasu, Sivashanmugam Karthikeyan, Periyasamy Giridharan and Nalilu Suchetha Kumari

    Citation: Organic and Medicinal Chemistry Letters 2013 3:6

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  21. Content type: Original article

    The aim of this study was to identify, quantify, and compare the phytochemical contents, antioxidant capacities, and antibacterial activities of Aloe vera lyophilized leaf gel (LGE) and 95% ethanol leaf gel extra...

    Authors: Fatemeh Nejatzadeh-Barandozi

    Citation: Organic and Medicinal Chemistry Letters 2013 3:5

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  22. Content type: Original article

    Glycosmis is a genus of evergreen glabrous shrub and distributed all over India. It possesses various medicinal properties and is used in indigenous medicine for cough, rheumatism, anemia, and jaundice. Glycosmi...

    Authors: Mohammad Faheem Khan, Nisha Negi, Rajnikant Sharma and Devendra Singh Negi

    Citation: Organic and Medicinal Chemistry Letters 2013 3:4

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  23. Content type: Original article

    The combretastatins are a class of natural stilbenoids. These molecules generally share three common structural features: a trimethoxy "A"-ring, a "B"-ring containing substituent often at C3′ and C4′, and an e...

    Authors: Sunil Kumar, Samir Mehndiratta, Kunal Nepali, Manish K Gupta, Surrinder Koul, Parduman R Sharma, Ajit K Saxena and Kanaya L Dhar

    Citation: Organic and Medicinal Chemistry Letters 2013 3:3

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  24. Content type: Short communication

    Synthesized arylidene derivatives of rhodanine and 2,4-thiazolidiendione have potent pharmacological activities, and these are also key substrates for the preparation of clinically used antidiabetics.

    Authors: Suresh and Jagir Singh Sandhu

    Citation: Organic and Medicinal Chemistry Letters 2013 3:2

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  25. Content type: Original article

    The benzhydryl ether moiety is widely distributed in nature and constitutes a key structural motif in numerous molecules of significant biological potential and of prospective clinical uses. Solvent-free and c...

    Authors: Goutam Brahmachari and Bubun Banerjee

    Citation: Organic and Medicinal Chemistry Letters 2013 3:1

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  26. Content type: Original article

    Free radicals are well known for playing a dual role in our body- deleterious as well as beneficial. It includes a metabolic pathway for its generation. Oxidative stress in our body occurs due to excessive gen...

    Authors: Tabassum Bano, Nitin Kumar and Rupesh Dudhe

    Citation: Organic and Medicinal Chemistry Letters 2012 2:34

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  27. Content type: Original article

    This experiment was conducted to evaluate the effect of different amounts of fertilizers on the polysaccharides of Aloe vera plant. There were four different treatments, viz. T1 = 150% N, T2 = 150% P, T3 = 150% K...

    Authors: Fatemeh Nejatzadeh-Barandozi and Sattar Tahmasebi Enferadi

    Citation: Organic and Medicinal Chemistry Letters 2012 2:33

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  28. Content type: Original article

    The endocannabinoid system is involved in many physiological and pathological processes. Two receptors (cannabinoid receptor type 1 (CB1) and type 2 (CB2)) are known so far. Many unwanted psychotic side effect...

    Authors: Thomas Rühl, Winnie Deuther-Conrad, Steffen Fischer, Robert Günther, Lothar Hennig, Harald Krautscheid and Peter Brust

    Citation: Organic and Medicinal Chemistry Letters 2012 2:32

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  29. Content type: Original article

    The biological importance of members of genus Ferula promoted us to investigate the leaves of Ferula vesceritensis Coss et Dur. (endemic plant) previously not investigated. This study presents the chemical compos...

    Authors: Amar Zellagui, Noueddine Gherraf and Salah Rhouati

    Citation: Organic and Medicinal Chemistry Letters 2012 2:31

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  30. Content type: Original article

    More than 15,000 marine products have been described up to now; Sponges are champion producers, concerning the diversity of products that have been found. Most bioactive compounds from sponges were classified ...

    Authors: Mohamed Shaaban, Howaida I Abd-Alla, Amal Z Hassan, Hanan F Aly and Mohamed A Ghani

    Citation: Organic and Medicinal Chemistry Letters 2012 2:30

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  31. Content type: Original article

    An antibacterial is a substance that either kills bacteria or slows their growth. Antifungal are the agents that use drugs for treatment of fungal infections. 5-Chloro-1,3-benzoxazol-2(3 H)-one (5-Chloro Benzo...

    Authors: Priya R Modiya and Chhaganbhai N Patel

    Citation: Organic and Medicinal Chemistry Letters 2012 2:29

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  32. Content type: Original article

    Caspase-3 inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death. Interest in caspase-3 as a therapeutic target has led many to pursue the development of...

    Authors: Dodheri Syed Samiulla, Andra Naidu, Gummadi Venkateshwar Rao and Murali Ramachandra

    Citation: Organic and Medicinal Chemistry Letters 2012 2:27

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  33. Content type: Original article

    The present paper describes the isolation and characterization of two new aliphatic δ-lactones along with three glycerides and n-nonadecanyl cetoleate from the fruits of Coriandrum sativum L. (Apiaceae). The stru...

    Authors: Kamran J Naquvi, Mohammed Ali and Javed Ahmad

    Citation: Organic and Medicinal Chemistry Letters 2012 2:28

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  34. Content type: Original article

    1,2,4-Triazole derivatives have received much attention due to their versatile biological properties including antibacterial, antifungal, anticonvulsant, antiinflammatory, anticancer, and antiproliferative pro...

    Authors: Xiang Li, Xue-Qiang Li, He-Mei Liu, Xue-Zhang Zhou and Zhi-Hui Shao

    Citation: Organic and Medicinal Chemistry Letters 2012 2:26

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  35. Content type: Original article

    Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity and account for nearly 30% of all deaths each year worldwide. High levels of cholesterol are an import...

    Authors: Mahesh Kumar Teli and Rajanikant G K

    Citation: Organic and Medicinal Chemistry Letters 2012 2:25

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  36. Content type: Original article

    Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically act...

    Authors: Rosario Astrid Vargas Cárdenas, Blanca Olinda Quintanilla Leal, Ashwini Reddy, Debasish Bandyopadhyay and Bimal K Banik

    Citation: Organic and Medicinal Chemistry Letters 2012 2:24

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  37. Content type: Original article

    The discovery of clinically relevant inhibitors of HIV-RT for antiviral therapy has proven to be a challenging task. To identify novel and potent HIV-RT inhibitors, the quantitative structure–activity relation...

    Authors: Shailesh V Jain, Manjunath Ghate, Kamlendra S Bhadoriya, Sanjaykumar B Bari, Amar Chaudhari and Jayshri S Borse

    Citation: Organic and Medicinal Chemistry Letters 2012 2:22

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  38. Content type: Original article

    Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC50 values of the synthesized compounds against the proliferation of human hep...

    Authors: Uttara Soumyanarayanan, Varadaraj G Bhat, Sidhartha S Kar and Jesil A Mathew

    Citation: Organic and Medicinal Chemistry Letters 2012 2:23

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  39. Content type: Original article

    Green catalyst fly ash: H2SO4 was prepared by mixing fly ash and sulphuric acid. Microwave irradiations are applied for solid phase cyclization of 5-bromo-2-thienyl chalcones and phenyl hydrazine hydrate in the p...

    Authors: Ramalingam Sasikala, Kannan Thirumurthy, Perumal Mayavel and Ganesamoorthy Thirunarayanan

    Citation: Organic and Medicinal Chemistry Letters 2012 2:20

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  40. Content type: Original article

    Extracts from the marine algae Cymopolia barbata have previously shown promising pharmacological activity including antifungal, antitumor, antimicrobial, and antimutagenic properties. Even though extracts have de...

    Authors: Simone Badal, Winklet Gallimore, George Huang, Tzuen-Rong Jeremy Tzeng and Rupika Delgoda

    Citation: Organic and Medicinal Chemistry Letters 2012 2:21

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  41. Content type: Original article

    We previously described the visceral antinociceptive property of α-bisabolol (BISA) in mouse models of visceral nociception induced by cyclophosphamide and mustard oil (MO). This study examined the effect of B...

    Authors: Gerlânia de Oliveira Leite, Cícera Norma Fernandes, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa and Adriana Rolim Campos

    Citation: Organic and Medicinal Chemistry Letters 2012 2:18

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  42. Content type: Original article

    Natural products isolated from plant sources have been demonstrated as potential candidates against several ailments. The scientific investigations on the underlying principles of phytotherapy can pave way for...

    Authors: Musiri Maruthai Senthamilselvi, Devarayan Kesavan and Nagarajan Sulochana

    Citation: Organic and Medicinal Chemistry Letters 2012 2:19

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  43. Content type: Original article

    Gum ghatti is a proteinaceous edible, exudate tree gum of India and is also used in traditional medicine. A facile and ecofriendly green method has been developed for the synthesis of silver nanoparticles from...

    Authors: Aruna Jyothi Kora, Sashidhar Rao Beedu and Arunachalam Jayaraman

    Citation: Organic and Medicinal Chemistry Letters 2012 2:17

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  44. Content type: Original article

    Aminoquinoline/steroid conjugates were synthesized based on the fact that steroid transporters have been shown to accept and carry a variety of drugs. So, in continuing our research of antileishmanial and anti...

    Authors: Luciana MR Antinarelli, Arturene ML Carmo, Fernando R Pavan, Clarice Queico F Leite, Adilson D Da Silva, Elaine S Coimbra and Deepak B Salunke

    Citation: Organic and Medicinal Chemistry Letters 2012 2:16

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  45. Content type: Original article

    The nuclear-chemical method brought unique opportunity for synthesis of unknown and hardly available organic compounds. Presence of tritium labeling allows one-step preparation of radioactive markers for the i...

    Authors: Nadezhda E Shchepina, Viktor V Avrorin, Gennady A Badun, Nikolay A Bumagin, Scott B Lewis and Sergey N Shurov

    Citation: Organic and Medicinal Chemistry Letters 2012 2:14

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  46. Content type: Original article

    Aryl azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted butynyl 1,2,3-triazoles in a domino fashion, which upon Cu(I) catalyzed 1,3-dipolar cycloaddition with aryl azides afforded ...

    Authors: Abid H Banday, Shameem A Shameem and Bashir A Ganai

    Citation: Organic and Medicinal Chemistry Letters 2012 2:13

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