A rapid, convenient, solventless green approach for the synthesis of oximes using grindstone chemistry

Organic and Medicinal Chemistry Letters

Table 1 Preparation of aldoximes and ketoximes 2a

Entry	Time (min)	Isolated yield (%)	Mp/°C (Lit.)
a	1.5	95	-(35)^b
b	2	96	105 (107)^b
c	2	96	130 (133)^b
d	2	95	120 (122)^b
e	2	>98	75 (80)^b
f	3	95	74 (72)^b
g	2.5	98	128 (132)^b
h	2	95	72 (-)^c
i	2	>98	128 (132-136)^b
j	2	>98	135 (139)^b
k	6	88	197 (195.5-198)^b
l	3	96	-(52)^b
m	5.5	92	-(57)^b
n	6	95	86 (91)^b
o	7	>98	56 (59)^b
p	6.5	>98	86 (88)^b
q	20	60	140 (144)^b

^aAll compounds were characterized on the basis of IR,¹H and¹³C NMR spectral data, Mass spectrometry data and m_p.
^b(i) Furniss BS, Hannaford AJ, Smith PWG, Tatchell AR (2008) Vogel's textbook of practical organic chemistry, 5th edn. Pearson Education, Dorling Kindersley (India). (ii) Alfa-Aesar Research Chemicals, Metals and Materials catalogue, 2008-2009.
^cNot found in the literature.