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Table 2 In vitro antifungal activities of compounds 8a-q and 11

From: Design, synthesis and antimicrobial evaluation of novel 2-aryl-thiazolidin-4-one derivatives

Compound

MIC (μg/mL)

 

Ca

Cn

Ss

Tm

Af

Cp

8a

> 50

> 50

> 50

50

> 50

> 50

8b

> 50

> 50

> 50

> 50

> 50

> 50

8c

> 50

> 50

> 50

> 50

> 50

> 50

8d

> 50

> 50

> 50

> 50

> 50

> 50

8e

> 50

> 50

> 50

> 50

> 50

> 50

8f

> 50

> 50

> 50

> 50

> 50

> 50

8g

> 50

> 50

50

50

> 50

> 50

8h

> 50

> 50

50

50

> 50

> 50

8i

> 50

> 50

50

50

> 50

> 50

8j

> 50

> 50

> 50

50

50

> 50

8k

> 50

> 50

> 50

50

> 50

> 50

8l

> 50

> 50

> 50

50

> 50

> 50

8m

> 50

> 50

> 50

50

> 50

> 50

8n

> 50

> 50

> 50

50

> 50

> 50

8o

> 50

> 50

> 50

50

> 50

> 50

8p

> 50

> 50

> 50

50

> 50

> 50

8q

> 50

> 50

> 50

50

> 50

> 50

11

> 50

> 50

> 50

> 50

> 50

> 50

Ketoconazole

0.002

0.001

0.031

4.0

2.0

0.031

Fluconazole

0.5

1.0

2.0

1.0

2.0

1.0

  1. Ca, C. albicans; Cn, C. neoformans; Ss, S. schenckii; Tm, T. mentagrophytes; Af, A. fumigatus; Cp, C. parapsilosis (ATCC-22019).