Organic and Medicinal Chemistry Letters

Table 1 IC ₅₀ values (µM) obtained from the interaction of isomers of PBQs with colon cancer cell line (HT29) and the normal colon cell line (CCD18Co) along with positive controls

From: Cytotoxic and potent CYP1 inhibitors from the marine algae Cymopolia barbata

Compound	Cell lines
	CCD18 Co	HT29	HepG	MCF-7
PBQ1	NI	NI	NI	NI
PBQ2	55.65 ± 3.28	19.82 ± 0.46	NI	NI
Tamoxifen	NA	NA	NA	17.28 ± 0.06
Fluorouracil	55.51 ± 3.71	23.50 ± 1.12	ND	ND
Doxorubicin	NA	NA	18.61 ± 0.58	NA

Key NI, no impact (<10% inhibition at 60 μM); NA, not applicable; ND, not determined.

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