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Table 1 Structural details and percentage yield of compounds 3a to 3 l

From: Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study

Compound code R R 1 Yield (%) Compound code R R 1 Yield (%)
3a H 82 3 g 4-Cl 81
3b H 80 3 h 4-Cl 83
3c H 82 3i 4-Cl 83
3d 4-F 84 3j 2-Cl 83
3e 4-F 86 3 k 2-Cl 80
3f 4-F 84 3 l 2-Cl 86
  1. R, substitution on the phenyl ring; R1, substituted cyclic amine (as depicted in Scheme 1).