Organic and Medicinal Chemistry Letters

Table 1 Structural details and percentage yield of compounds 3a to 3 l

From: Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study

Compound code	R	R ₁	Yield (%)	Compound code	R	R ₁	Yield (%)
3a	H		82	3 g	4-Cl		81
3b	H		80	3 h	4-Cl		83
3c	H		82	3i	4-Cl		83
3d	4-F		84	3j	2-Cl		83
3e	4-F		86	3 k	2-Cl		80
3f	4-F		84	3 l	2-Cl		86

R, substitution on the phenyl ring; R₁, substituted cyclic amine (as depicted in Scheme 1).

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