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Organic and Medicinal Chemistry Letters

Table 2 IC 50 of compounds 3a-l by MTT assay

From: Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study

Compound code

IC 50 a(μg/mL)

 

HepG2

HeLa

3a

180

216

3b

166

189

3c

207

240

3d

178

229

3e

194

-

3f

269

346

3 g

124

187

3 h

120

217

3i

218

374

3j

192

261

3 k

191

398

3 l

218

374

  1. a50% inhibitory concentration. HepG2, human hepatocellular carcinoma; HeLa, human epithelial carcinoma.
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