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Organic and Medicinal Chemistry Letters

Table 2 IC 50 of compounds 3a-l by MTT assay

From: Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study

Compound code IC 50 a(μg/mL)
  HepG2 HeLa
3a 180 216
3b 166 189
3c 207 240
3d 178 229
3e 194 -
3f 269 346
3 g 124 187
3 h 120 217
3i 218 374
3j 192 261
3 k 191 398
3 l 218 374
  1. a50% inhibitory concentration. HepG2, human hepatocellular carcinoma; HeLa, human epithelial carcinoma.
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