Synthesis and evaluation of substituted diphenyl-1,3,4-oxadiazole derivatives for central nervous system depressant activity

Organic and Medicinal Chemistry Letters

Table 3 Antianxiety activity of synthesized compounds

Number	Compound	Dose (mg kg^-1)	Number of entries in open arms (Mean ± S.E.M)	Average time spent in open arms (Mean ± S.E.M)
1.	Control	10	2.10 ± 0.23	9.77 ± 0.27
2.	Standard	10	12.66 ± 0.33	32.66 ± 0.33
3.	XIII	10	13.33 ± 0.21***	68.00 ± 0.36***
4.	XIV	10	17.00 ± 0.36***	62.33 ± 0.21**
5.	XV	10	21.50 ± 0.42***	76.83 ± 0.30***
6.	XVI	10	8.83 ± 0.30***	45.83 ± 0.30**
7.	XVII	10	13.66 ± 0.42	52.66 ± 0.33*

Values are mean ± SEM of six animals in each group. Statistical significance versus standard (***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05)