Synthesis and evaluation of substituted diphenyl-1,3,4-oxadiazole derivatives for central nervous system depressant activity

Organic and Medicinal Chemistry Letters

Table 7 Physico-chemical data of the synthesized compounds (XIII-XXV)

Compound	R	R'	Molecular formula	Molecular weight	% Yield	m.p. (°C)	Rf^{solvent system}
XIII	4-OH	4-Cl	C₁₄H₉ClN₂O₂	272.69	74.11	95-97	0.78^a
XIV	4-NO2	4-Cl	C₁₄H₈ClN₃O₃	301.68	82.22	165-167	0.75^a
XV	4-NO2	4-NO2	C₁₄H₈N₄O₅	312.24	95.24	127-129	0.67^a
XVI	4-NO2	4-NH2	C₁₄H₈ClN₃O₃	301.68	78.59	178-180	0.75^a
XVII	4-OH	4-NH2	C₁₄H₁₁N₃O₂	253.26	65.26	106-108	0.61^b
XVIII	4-NO2	2-Br	C₁₄H₈BrN₃O₃	346.14	86.01	120-122	0.82^a
XIX	4-NH2	4-Cl	C₁₄H₁₀ClN₃O	271.7	78.06	175-177	0.55^b
XX	4-NO2	4-OH	C₁₄H₉N₃O₄	283.24	64.79	104-107	0.66^b
XXI	4-OH	2-Br	C₁₄H₉BrN₂O₂	317.14	52.36	102-104	0.74^b
XXII	4-NO2	H	C₁₄H₉N₃O₃	267.24	81.79	104-106	0.81^a