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Table 2 Percentage growth inhibition by sesquiterpenes (1 to 7)

From: Cytotoxic compounds from Laurencia pacifica

  Compound
Cell line 1 2 3 4 5 6/7
HT29a 60 ± 3 12 ± 2 12 ± 5 >100 <10 10 ± 5
U87b 25 ± 2 13 ± 6 15 ± 7 52 ± 2 12 ± 4 15 ± 6
MCF-7c 81 ± 6 <10 <10 >100 <10 <10
A2780d 65 ± 5 <10 <10 99 ± 1 <10 <10
H460e 11 ± 1 <10 <10 71 ± 1 <10 <10
A431f 86 ± 1 <10 <10 >100 <10 <10
Du145g 41 ± 1 23 ± 6 18 ± 3 92 ± 2 18 ± 2 17 ± 3
BE2-Ch >100 <10 <10 >100 <10 <10
SJ-G2b 40 ± 5 <10 10 ± 3 >100 12 ± 3 14 ± 3
MIAi 47 ± 2 12 ± 4 17 ± 3 92 ± 2 18 ± 3 19 ± 2
SMAj 34 ± 8 <10 <10 95 ± 1 <10 <10
MCF10Ak 10 ± 6 <10 <10 31 ± 10 <10 <10
  1. Isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), and a 1:1 mixture of the 3α-hydroxydebromoaplysin (6) and 10-bromo-1,7-dien-3-ol (7) against a panel of cancer and non-cancer derived cell lines at a single dose (25 μM). Values are measured relative to an untreated control. aColon; bglioblastoma; cbreast; dovarian; elung; fskin; gprostate; hneuroblastoma; ipancreas; jglioblastoma (murine); kbreast (normal).