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Table 2 Percentage growth inhibition by sesquiterpenes (1 to 7)

From: Cytotoxic compounds from Laurencia pacifica

 

Compound

Cell line

1

2

3

4

5

6/7

HT29a

60 ± 3

12 ± 2

12 ± 5

>100

<10

10 ± 5

U87b

25 ± 2

13 ± 6

15 ± 7

52 ± 2

12 ± 4

15 ± 6

MCF-7c

81 ± 6

<10

<10

>100

<10

<10

A2780d

65 ± 5

<10

<10

99 ± 1

<10

<10

H460e

11 ± 1

<10

<10

71 ± 1

<10

<10

A431f

86 ± 1

<10

<10

>100

<10

<10

Du145g

41 ± 1

23 ± 6

18 ± 3

92 ± 2

18 ± 2

17 ± 3

BE2-Ch

>100

<10

<10

>100

<10

<10

SJ-G2b

40 ± 5

<10

10 ± 3

>100

12 ± 3

14 ± 3

MIAi

47 ± 2

12 ± 4

17 ± 3

92 ± 2

18 ± 3

19 ± 2

SMAj

34 ± 8

<10

<10

95 ± 1

<10

<10

MCF10Ak

10 ± 6

<10

<10

31 ± 10

<10

<10

  1. Isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), and a 1:1 mixture of the 3α-hydroxydebromoaplysin (6) and 10-bromo-1,7-dien-3-ol (7) against a panel of cancer and non-cancer derived cell lines at a single dose (25 μM). Values are measured relative to an untreated control. aColon; bglioblastoma; cbreast; dovarian; elung; fskin; gprostate; hneuroblastoma; ipancreas; jglioblastoma (murine); kbreast (normal).