Synthesis and antileishmanial evaluation of some 2,3-disubstituted-4(3H)-quinazolinone derivatives

Organic and Medicinal Chemistry Letters

Table 1 Physical constants and percent yield of the synthesized compounds

Test compound	Molecular formula	Molecular weight (g/mol)	% yield	Melting point (°C)	R_fvalues [CHCl₃/C₆H₆(9:1)]
6	C₂₂H₁₇ClN₂O	360.85	68.3	201 to 203	0.520
7	C₂₃H₁₉ClN₂O	374.87	65.2	189 to 191	0.577
8	C₂₃H₁₈N₃O₃	384.41	74.8	214 to 216	0.422
9	C₂₃H₁₈N₃O₃	384.41	76.2	235 to 237	0.642
11	C₂₆H₂₄N₂O₄	428.49	86.4	151 to 153	0.781
12	C₂₂H₁₈N₂O₂	342.40	80.3	298 to 300	0.524
13	C₂₄H₂₂N₂O₃	386.45	82.2	196 to 198	0.711