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  1. Content type: Original article

    The plasma membrane redox system (PMRS) has extensively been studied in erythrocytes. The PMRS plays an important role in maintaining plasma redox balance and provides a protective mechanism against oxidative ...

    Authors: Rajesh Kumar Kesharwani, Durg Vijay Singh, Krishna Misra and Syed Ibrahim Rizvi

    Citation: Organic and Medicinal Chemistry Letters 2012 2:12

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  2. Content type: Short communication

    The classical Paal-Knorr reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful pyrrole derivatives.

    Authors: Mandira Banik, Bianca Ramirez, Ashwini Reddy, Debasish Bandyopadhyay and Bimal K Banik

    Citation: Organic and Medicinal Chemistry Letters 2012 2:11

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  3. Content type: Original

    Annulated benzothiazoloquinazolines have been synthesized by a diversity oriented simple and convenient synthesis involving one-pot three-component reaction of substituted 2-aminobenzothiazoles with α-tetralon...

    Authors: Mahendra Kumar, Kailash Sharma and Dinesh Kumar Sharma

    Citation: Organic and Medicinal Chemistry Letters 2012 2:10

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  4. Content type: Original article

    The chemical constituents and biological activities of the terrestrial Aspergillus flavipes MM2 isolated from Egyptian rice hulls are reported. Seven bioactive compounds were obtained, of which one sterol: ergost...

    Authors: Mohamed MS Nagia, Mohammad Magdy El-Metwally, Mohamed Shaaban, Soheir M El-Zalabani and Atef G Hanna

    Citation: Organic and Medicinal Chemistry Letters 2012 2:9

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  5. Content type: Short communication

    AT1 receptor antagonists are clinically effective drugs for the treatment of hypertension, cardiovascular, and related disorders. In an attempt to identify new AT1 receptor antagonists, a pharmacophore-based virt...

    Authors: Mahima Pal and Sarvesh Paliwal

    Citation: Organic and Medicinal Chemistry Letters 2012 2:7

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  6. Content type: Original article

    Substituted 1,3,4-oxadiazoles are of considerable pharmaceutical interest. 2,5-Substituted diphenyl-1,3,4-oxadiazoles are associated with diverse biological activities by the virtue of -N = C-O- grouping. In t...

    Authors: Poonam Singh, Pramod Kumar Sharma, Jitendra Kumar Sharma, Anshu Upadhyay and Nitin Kumar

    Citation: Organic and Medicinal Chemistry Letters 2012 2:8

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  7. Content type: Original article

    Eight bioactive pyrone derivatives were identified from the culture of Alternaria alternata strain D2006, isolated from the marine soft coral Denderonephthya hemprichi, which was selected as its profound antimicr...

    Authors: Mohamed Shaaban, Khaled A Shaaban and Mohamed S Abdel-Aziz

    Citation: Organic and Medicinal Chemistry Letters 2012 2:6

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  8. Content type: Original

    We have identified a series of compounds that inhibit protein synthesis in bacteria. Initial IC50's in aminoacylation/translation (A/T) assays ranged from 3 to14 μM. This series of compounds are variations on a 5...

    Authors: Joseph W Guiles, Andras Toro, Urs A Ochsner and James M Bullard

    Citation: Organic and Medicinal Chemistry Letters 2012 2:5

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  9. Content type: Original

    Adverse antimicrobial activities of thiosemicarbazone (TSC) and Schiff base derivatives have widely been studied by using different kinds of microbes, in addition different methods were used to assay the antio...

    Authors: Ahmed A Al-Amiery, Yasmien K Al-Majedy, Heba H Ibrahim and Ali A Al-Tamimi

    Citation: Organic and Medicinal Chemistry Letters 2012 2:4

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  10. Content type: Original

    Herpes simplex virus type-1 (HSV-1) is the primary cause of facial lesions (mouth, lips, and eyes) in humans. The widespread use of acyclovir and nucleoside analogues has led to emergence of HSV strains that a...

    Authors: Alice MR Bernardino, Alexandre R Azevedo, Luiz CS Pinheiro, Júlio C Borges, Izabel CP Paixão, Milene Mesquita, Thiago ML Souza and Maurício S dos Santos

    Citation: Organic and Medicinal Chemistry Letters 2012 2:3

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  11. Content type: Original

    Several species of the genus Launaea are used in folk medicine such as in bitter stomachic, skin diseases, and reported to have antitumor, insecticide, and cytotoxic activities. The antimicrobial activities of co...

    Authors: Amar Zellagui, Noureddine Gherraf, Segni Ladjel and Samir Hameurlaine

    Citation: Organic and Medicinal Chemistry Letters 2012 2:2

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  12. Content type: Original article

    Investigation of the aerial parts of the Egyptian medicinal plant Ammi majus L. led to isolation of new coumarin, 6-hydroxy-7-methoxy-4 methyl coumarin (2) and 6-hydroxy-7-methoxy coumarin (3); this is the first ...

    Authors: Yasser Abdelaal Selim and Nabil Hassan Ouf

    Citation: Organic and Medicinal Chemistry Letters 2012 2:1

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  13. Content type: Original

    Thiazolidine-2, 4-diones (TZDs) have become a pharmacologically important class of heterocyclic compounds since their introduction in the form of glitazones into the clinical use for the treatment of type 2 di...

    Authors: Deepak K Aneja, Poonam Lohan, Sanjiv Arora, Chetan Sharma, Kamal R Aneja and Om Prakash

    Citation: Organic and Medicinal Chemistry Letters 2011 1:15

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  14. Content type: Original

    The protein kinase A (PKA)-catalyzed phosphorylation of peptide substrate RRASVA analogs, containing Nβ-Me-aza-β3-amino acid residues in all subsequent positions, was studied. This work follows along the lines of...

    Authors: Ksenija Kisseljova, Michèle Baudy-Floc'h, Aleksei Kuznetsov and Jaak Järv

    Citation: Organic and Medicinal Chemistry Letters 2011 1:16

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  15. Content type: Original

    In our continued search for bioactive compounds from plants, conscious effort is being made to rapidly analyze ethnobotanical plants used for treating various ailments by traditional healers before this inform...

    Authors: Isaac A Bello, George I Ndukwe, Oladimeji T Audu and James D Habila

    Citation: Organic and Medicinal Chemistry Letters 2011 1:14

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  16. Content type: Original

    Synthesis of oximes is an important reaction in organic chemistry, because these versatile oximes are used for protection, purification, and characterization of carbonyl compounds. Nitriles, amides via Beckman...

    Authors: Lakhinath Saikia, Jejiron Maheswari Baruah and Ashim Jyoti Thakur

    Citation: Organic and Medicinal Chemistry Letters 2011 1:12

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  17. Content type: Original

    The classical Strecker reaction is one of the simplest and most economical methods for the synthesis of racemic α-aminonitriles (precursor of α-amino acids) and pharmacologically useful compounds.

    Authors: Debasish Bandyopadhyay, Juliana M Velazquez and Bimal K Banik

    Citation: Organic and Medicinal Chemistry Letters 2011 1:11

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  18. Content type: Original

    An efficient, one-pot synthesis was developed for 3-aminoalkylated indoles by three-component coupling reaction of aldehydes, N-methylanilines, and indoles using AgOTf as a catalyst. A series of twenty 3-aminoalk...

    Authors: Vagicherla Kameshwara Rao, Madharam Sudershan Rao, Navin Jain, Jitendra Panwar and Anil Kumar

    Citation: Organic and Medicinal Chemistry Letters 2011 1:10

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  19. Content type: Original

    Novel 1,1'-(5,5'-(1,4-phenylene)bis(3-aryl-1H-pyrazole-5,1-(4H,5H)-diyl))diethanones 7-12 were tested for their antimicrobial activity by disc diffusion and twofold serial dilution method against the tested bacte...

    Authors: Vijayakumar Kanagarajan, Muthuvel Ramanathan Ezhilarasi and Mannathusamy Gopalakrishnan

    Citation: Organic and Medicinal Chemistry Letters 2011 1:8

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  20. Content type: Short communication

    Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate ha...

    Authors: Luis Canales, Debasish Bandyopadhyay and Bimal K Banik

    Citation: Organic and Medicinal Chemistry Letters 2011 1:9

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  21. Content type: Original

    Focused structure-activity relationships of isoindoline class DPP-IV inhibitors have led to the discovery of 4b as a highly selective, potent inhibitor of DPP-IV. In vivo studies in Wistar/ST rats showed that 4b ...

    Authors: Noriyasu Kato, Mitsuru Oka, Takayo Murase, Masahiro Yoshida, Masao Sakairi, Mirensha Yakufu, Satoko Yamashita, Yoshika Yasuda, Aya Yoshikawa, Yuji Hayashi, Masahiro Shirai, Yukie Mizuno, Mitsuaki Takeuchi, Mitsuhiro Makino, Motohiro Takeda and Takuji Kakigami

    Citation: Organic and Medicinal Chemistry Letters 2011 1:7

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  22. Content type: Original

    A facile synthesis of azabicycloadducts is described by 1,3-dipolar cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid in the presence of various electron rich and electron deficient dip...

    Authors: Sonali Verma, Johnson George, Saurabh Singh, Pushpa Pardasani and Ramchand Pardasani

    Citation: Organic and Medicinal Chemistry Letters 2011 1:6

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  23. Content type: Original

    Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates (1,4-DHP) have now been recognized as vital drugs. Some of these derivatives such as amlodipine, felodipine, isradipine, etc. have been commercialize...

    Authors: Om Prakash, Khalid Hussain, Ravi Kumar, Deepak Wadhwa, Chetan Sharma and Kamal R Aneja

    Citation: Organic and Medicinal Chemistry Letters 2011 1:5

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  24. Content type: Original

    Novel 2-arylthiazolidin-4-one derivatives (8a-q and 11) have been synthesized in good-to-excellent yields (70-96%) by one-pot three-component condensation-cyclization reaction of aromatic or aliphatic primary ami...

    Authors: Davinder Prasad, Awanit Kumar, Praveen Kumar Shukla and Mahendra Nath

    Citation: Organic and Medicinal Chemistry Letters 2011 1:4

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  25. Content type: Original

    QSAR is among the most extensively used computational methodology for analogue-based design. The application of various descriptor classes like quantum chemical, molecular mechanics, conceptual density functio...

    Authors: Mohammed Hussaini Bohari, Hemant Kumar Srivastava and Garikapati Narahari Sastry

    Citation: Organic and Medicinal Chemistry Letters 2011 1:3

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  26. Content type: Original

    Fused heterocyclic 1,2,4-triazoles have acquired much importance because of their interesting biological properties. Although a number of methods have been reported in the literature which includes oxidation w...

    Authors: Om Prakash, Khalid Hussain, Deepak K Aneja, Chetan Sharma and Kamal R Aneja

    Citation: Organic and Medicinal Chemistry Letters 2011 1:1

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  27. Content type: Original

    Ring opening of phthalic anhydride has been carried out in acetic acid with glycine, β-alanine, L-phenylalanine, and 4-aminobenzoic acid to yield, respectively, 2-{[(carboxymethyl)amino]carbonyl}benzoic acid (I),...

    Authors: MI Khan, Saima Gul, Iqbal Hussain, Murad Ali Khan, Muhammad Ashfaq, Inayat-Ur-Rahman, Farman Ullah, Gulrez Fatima Durrani, Imam Bakhsh Baloch and Rubina Naz

    Citation: Organic and Medicinal Chemistry Letters 2011 1:2

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