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  1. Original article

    Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors

    The combretastatins are a class of natural stilbenoids. These molecules generally share three common structural features: a trimethoxy "A"-ring, a "B"-ring containing substituent often at C3′ and C4′, and an e...

    Sunil Kumar, Samir Mehndiratta, Kunal Nepali, Manish K Gupta, Surrinder Koul, Parduman R Sharma, Ajit K Saxena and Kanaya L Dhar

    Organic and Medicinal Chemistry Letters 2013 3:3

    Published on: 3 March 2013

  2. Original article

    Free radical scavenging properties of pyrimidine derivatives

    Free radicals are well known for playing a dual role in our body- deleterious as well as beneficial. It includes a metabolic pathway for its generation. Oxidative stress in our body occurs due to excessive gen...

    Tabassum Bano, Nitin Kumar and Rupesh Dudhe

    Organic and Medicinal Chemistry Letters 2012 2:34

    Published on: 14 November 2012

  3. Original article

    FT-IR study of the polysaccharides isolated from the skin juice, gel juice, and flower of Aloe vera tissues affected by fertilizer treatment

    This experiment was conducted to evaluate the effect of different amounts of fertilizers on the polysaccharides of Aloe vera plant. There were four different treatments, viz. T1 = 150% N, T2 = 150% P, T3 = 150% K...

    Fatemeh Nejatzadeh-Barandozi and Sattar Tahmasebi Enferadi

    Organic and Medicinal Chemistry Letters 2012 2:33

    Published on: 24 October 2012

  4. Original article

    Cannabinoid receptor type 2 (CB2)-selective N-aryl-oxadiazolyl-propionamides: synthesis, radiolabelling, molecular modelling and biological evaluation

    The endocannabinoid system is involved in many physiological and pathological processes. Two receptors (cannabinoid receptor type 1 (CB1) and type 2 (CB2)) are known so far. Many unwanted psychotic side effect...

    Thomas Rühl, Winnie Deuther-Conrad, Steffen Fischer, Robert Günther, Lothar Hennig, Harald Krautscheid and Peter Brust

    Organic and Medicinal Chemistry Letters 2012 2:32

    Published on: 15 October 2012

  5. Original article

    Chemical composition and antibacterial activity of the essential oils of Ferula vesceritensis Coss et Dur. leaves, endemic in Algeria

    The biological importance of members of genus Ferula promoted us to investigate the leaves of Ferula vesceritensis Coss et Dur. (endemic plant) previously not investigated. This study presents the chemical compos...

    Amar Zellagui, Noueddine Gherraf and Salah Rhouati

    Organic and Medicinal Chemistry Letters 2012 2:31

    Published on: 3 September 2012

  6. Original article

    Chemical characterization, antioxidant and inhibitory effects of some marine sponges against carbohydrate metabolizing enzymes

    More than 15,000 marine products have been described up to now; Sponges are champion producers, concerning the diversity of products that have been found. Most bioactive compounds from sponges were classified ...

    Mohamed Shaaban, Howaida I Abd-Alla, Amal Z Hassan, Hanan F Aly and Mohamed A Ghani

    Organic and Medicinal Chemistry Letters 2012 2:30

    Published on: 16 August 2012

  7. Original article

    Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3

    Caspase-3 inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death. Interest in caspase-3 as a therapeutic target has led many to pursue the development of...

    Dodheri Syed Samiulla, Andra Naidu, Gummadi Venkateshwar Rao and Murali Ramachandra

    Organic and Medicinal Chemistry Letters 2012 2:27

    Published on: 16 July 2012

  8. Original article

    Two new aliphatic lactones from the fruits of Coriandrum sativum L.

    The present paper describes the isolation and characterization of two new aliphatic δ-lactones along with three glycerides and n-nonadecanyl cetoleate from the fruits of Coriandrum sativum L. (Apiaceae). The stru...

    Kamran J Naquvi, Mohammed Ali and Javed Ahmad

    Organic and Medicinal Chemistry Letters 2012 2:28

    Published on: 16 July 2012

  9. Original article

    Synthesis and evaluation of antitumor activities of novel chiral 1,2,4-triazole Schiff bases bearing γ-butenolide moiety

    1,2,4-Triazole derivatives have received much attention due to their versatile biological properties including antibacterial, antifungal, anticonvulsant, antiinflammatory, anticancer, and antiproliferative pro...

    Xiang Li, Xue-Qiang Li, He-Mei Liu, Xue-Zhang Zhou and Zhi-Hui Shao

    Organic and Medicinal Chemistry Letters 2012 2:26

    Published on: 3 July 2012

  10. Original article

    Microwave-assisted polystyrene sulfonate-catalyzed synthesis of novel pyrroles

    Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically act...

    Rosario Astrid Vargas Cárdenas, Blanca Olinda Quintanilla Leal, Ashwini Reddy, Debasish Bandyopadhyay and Bimal K Banik

    Organic and Medicinal Chemistry Letters 2012 2:24

    Published on: 22 June 2012

  11. Original article

    2D, 3D-QSAR and docking studies of 1,2,3-thiadiazole thioacetanilides analogues as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

    The discovery of clinically relevant inhibitors of HIV-RT for antiviral therapy has proven to be a challenging task. To identify novel and potent HIV-RT inhibitors, the quantitative structure–activity relation...

    Shailesh V Jain, Manjunath Ghate, Kamlendra S Bhadoriya, Sanjaykumar B Bari, Amar Chaudhari and Jayshri S Borse

    Organic and Medicinal Chemistry Letters 2012 2:22

    Published on: 12 June 2012

  12. Original article

    Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study

    Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC50 values of the synthesized compounds against the proliferation of human hep...

    Uttara Soumyanarayanan, Varadaraj G Bhat, Sidhartha S Kar and Jesil A Mathew

    Organic and Medicinal Chemistry Letters 2012 2:23

    Published on: 12 June 2012

  13. Original article

    Eco-friendly synthesis and antimicrobial activities of some 1-phenyl-3(5-bromothiophen-2-yl)-5-(substituted phenyl)-2-pyrazolines

    Green catalyst fly ash: H2SO4 was prepared by mixing fly ash and sulphuric acid. Microwave irradiations are applied for solid phase cyclization of 5-bromo-2-thienyl chalcones and phenyl hydrazine hydrate in the p...

    Ramalingam Sasikala, Kannan Thirumurthy, Perumal Mayavel and Ganesamoorthy Thirunarayanan

    Organic and Medicinal Chemistry Letters 2012 2:20

    Published on: 11 June 2012

  14. Original article

    Cytotoxic and potent CYP1 inhibitors from the marine algae Cymopolia barbata

    Extracts from the marine algae Cymopolia barbata have previously shown promising pharmacological activity including antifungal, antitumor, antimicrobial, and antimutagenic properties. Even though extracts have de...

    Simone Badal, Winklet Gallimore, George Huang, Tzuen-Rong Jeremy Tzeng and Rupika Delgoda

    Organic and Medicinal Chemistry Letters 2012 2:21

    Published on: 11 June 2012

  15. Original article

    Attenuation of visceral nociception by α-bisabolol in mice: investigation of mechanisms

    We previously described the visceral antinociceptive property of α-bisabolol (BISA) in mouse models of visceral nociception induced by cyclophosphamide and mustard oil (MO). This study examined the effect of B...

    Gerlânia de Oliveira Leite, Cícera Norma Fernandes, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa and Adriana Rolim Campos

    Organic and Medicinal Chemistry Letters 2012 2:18

    Published on: 21 May 2012

  16. Original article

    Size-controlled green synthesis of silver nanoparticles mediated by gum ghatti (Anogeissus latifolia) and its biological activity

    Gum ghatti is a proteinaceous edible, exudate tree gum of India and is also used in traditional medicine. A facile and ecofriendly green method has been developed for the synthesis of silver nanoparticles from...

    Aruna Jyothi Kora, Sashidhar Rao Beedu and Arunachalam Jayaraman

    Organic and Medicinal Chemistry Letters 2012 2:17

    Published on: 9 May 2012

  17. Original article

    Increase of leishmanicidal and tubercular activities using steroids linked to aminoquinoline

    Aminoquinoline/steroid conjugates were synthesized based on the fact that steroid transporters have been shown to accept and carry a variety of drugs. So, in continuing our research of antileishmanial and anti...

    Luciana MR Antinarelli, Arturene ML Carmo, Fernando R Pavan, Clarice Queico F Leite, Adilson D Da Silva, Elaine S Coimbra and Deepak B Salunke

    Organic and Medicinal Chemistry Letters 2012 2:16

    Published on: 2 May 2012

  18. Original article

    Pathways of ion–molecular interactions of nucleogenic phenyl cations with the nucleophilic centers of picolines

    The nuclear-chemical method brought unique opportunity for synthesis of unknown and hardly available organic compounds. Presence of tritium labeling allows one-step preparation of radioactive markers for the i...

    Nadezhda E Shchepina, Viktor V Avrorin, Gennady A Badun, Nikolay A Bumagin, Scott B Lewis and Sergey N Shurov

    Organic and Medicinal Chemistry Letters 2012 2:14

    Published on: 13 April 2012

  19. Original article

    Antimicrobial studies of unsymmetrical bis-1,2,3-triazoles

    Aryl azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted butynyl 1,2,3-triazoles in a domino fashion, which upon Cu(I) catalyzed 1,3-dipolar cycloaddition with aryl azides afforded ...

    Abid H Banday, Shameem A Shameem and Bashir A Ganai

    Organic and Medicinal Chemistry Letters 2012 2:13

    Published on: 4 April 2012

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